A piezoelectric nanoplatform for ultrasound-triggered ROS storm via synergistic piezo-catalytic and fenton reactions to eradicate bladder tumors

IF 5.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2025-09-22 DOI:10.1016/j.inoche.2025.115556

Yuxiang Wang , Hongyu Liu , Beizhang Zhang , Guannan Zhang , Hailong Hao

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Abstract

Sonodynamic therapy (SDT) is considered an effective method for treating bladder cancer, but the limited electron transfer of a single material and the hypoxic microenvironment of cancer limit the efficiency of SDT. Here, barium titanate (BTO) was prepared, and Cu was doped into BTO through hydrothermal synthesis and high-temperature annealing, followed by surface conjugation of tumor-specific proteins (BTO/Cu/PDA/Nectin-4). The Cu doping enhances the ferroelectric polarization of BTO and reduces its bandgap, facilitating electron transfer. Meanwhile, Cu can react with hydrogen peroxide (H₂O₂) via the Fenton reaction to generate reactive oxygen species (ROS), thereby enhancing the chemodynamic therapy (CDT) effect. The combination of SDT and CDT enhanced ROS production, and both in vitro and in vivo results demonstrated excellent cytotoxic effects and tumor suppression against bladder cancer cells. This combined SDT and CDT approach offers an effective therapeutic strategy for antitumor treatment.

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超声触发ROS风暴的压电纳米平台，通过协同压电催化和fenton反应根除膀胱肿瘤

声动力疗法（SDT）被认为是治疗膀胱癌的一种有效方法，但单一材料的有限电子转移和肿瘤的低氧微环境限制了SDT的效率。本文制备了钛酸钡（BTO），并通过水热合成和高温退火将Cu掺杂到BTO中，然后表面偶联肿瘤特异性蛋白（BTO/Cu/PDA/Nectin-4）。Cu掺杂增强了BTO的铁电极化，减小了其带隙，有利于电子转移。同时，Cu可以与过氧化氢（H2O2）通过Fenton反应生成活性氧（ROS），从而增强化学动力治疗（CDT）效果。SDT和CDT联合使用增强了ROS的产生，体外和体内实验结果均显示出对膀胱癌细胞的良好细胞毒作用和抑瘤作用。这种联合SDT和CDT的方法为抗肿瘤治疗提供了有效的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.