Hormonal cross-talk in DHA biosynthesis: Regulatory roles of auxin and jasmonic acid in Schizochytrium spp. and Crypthecodinium cohnii

IF 4.5 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Abdul Wakeel Umar , Naveed Ahmad , Ming Xu
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引用次数: 0

Abstract

Docosahexaenoic acid (DHA), a long-chain ω−3 fatty acid essential for human neurodevelopment, cardiovascular health, and immune function, is derived predominantly from fisheries, which is constrained by overfishing, pollutants, and rising global demand. Microalgae such as Schizochytrium spp. and Crypthecodinium cohnii offer a sustainable alternative, yet scalable DHA production requires deeper insight into the regulatory networks that control lipid metabolism under environmental stress. Here, we review emerging evidence positioning the crosstalk between auxin and jasmonic acid (JA) as a central regulatory hub integrating growth and stress signals to optimize DHA yield. Auxin enhances fatty acid elongation and triacylglycerol accumulation, while JA orchestrates stress-induced desaturation and lipid remodeling, together balancing carbon flux between energy storage and membrane stabilization. Our integrated models combine multi-omics approaches, genetic tools such as CRISPR/Cas9 and RNAi, and bioprocess strategies on how these hormones reshape transcriptional and metabolic networks to elevate DHA content. Furthermore, synthetic analogs, stress-hardening, and phytohormone integration offer solutions to industrial bottlenecks in DHA biosynthesis. By bridging hormone biology with biotechnology, auxin-JA crosstalk emerges as a tractable axis for sustainable microalgal DHA production to meet ecological and nutritional needs.
DHA生物合成中的激素串扰:生长素和茉莉酸在Schizochytrium spp.和Crypthecodinium cohnii .中的调节作用
二十二碳六烯酸(DHA)是一种对人类神经发育、心血管健康和免疫功能至关重要的长链ω - 3脂肪酸,主要来源于渔业,而渔业受到过度捕捞、污染物和全球需求上升的限制。Schizochytrium spp.和Crypthecodinium cohnii等微藻提供了一种可持续的替代方案,但可扩展的DHA生产需要更深入地了解环境压力下控制脂质代谢的调节网络。本文回顾了将生长素和茉莉酸(JA)之间的串扰定位为整合生长和胁迫信号以优化DHA产量的中心调控枢纽的新证据。生长素促进脂肪酸延伸和甘油三酯积累,而JA则协调应激诱导的去饱和和脂质重塑,共同平衡能量储存和膜稳定之间的碳通量。我们的集成模型结合了多组学方法、CRISPR/Cas9和RNAi等遗传工具,以及这些激素如何重塑转录和代谢网络以提高DHA含量的生物过程策略。此外,合成类似物、应力硬化和植物激素整合为DHA生物合成的工业瓶颈提供了解决方案。通过将激素生物学与生物技术相结合,生长素- ja串扰成为微藻可持续生产DHA的可处理轴,以满足生态和营养需求。
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来源期刊
Algal Research-Biomass Biofuels and Bioproducts
Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
9.40
自引率
7.80%
发文量
332
期刊介绍: Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
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