Comparative evaluation of antimicrobial properties and surface roughness of four maxillofacial prosthetic materials

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-09-24 DOI:10.1016/j.jobcr.2025.09.019

Zaihan Ariffin , Yanti Johari , Farhana Rahman , Suharni Mohamad , Nafij Bin Jamayet , James Dudley

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引用次数: 0

Abstract

Objectives

The adherence of microorganisms to the surfaces of maxillofacial prosthetic materials can cause surrounding tissue infections leading to discomfort, irritation and infection. It is therefore beneficial if maxillofacial prosthetic materials possess antimicrobial effects or resist microbial adherence. The purpose of this study was to compare the antimicrobial effect, surface roughness and microbial adherence of a locally produced modified polymethyl methacrylate maxillofacial prosthetic material with a commercially produced polymethyl methacrylate and two silicone elastomers against three microorganisms.

Methods

Four study groups were formed, each with 10 samples (n = 10): modified polymethyl methacrylate (m-PMMA), commercially produced polymethyl methacrylate (c-PMMA), silicone A-2000 (A-2000), and silicone A-2186 (A-2186). The microorganisms tested against the four prosthetic materials were Staphylococcus aureus (S. aureus), Streptococcus mutans (S. mutans), and Candida albicans (C. albicans). The antimicrobial effect, microbial adherence and surface roughness were assessed and scanning electron microscopy images examined surface roughness and microbial adherence.

Results

None of the tested materials showed antimicrobial activity against the evaluated microbial strains. Microbial adherence was significantly higher on silicone elastomers, with greater colony-forming units of both S. aureus and S. mutans compared to PMMA (p < 0.017). No significant difference was observed in C. albicans adherence between the silicone elastomers and PMMA. Surface roughness analysis revealed a statistically significant difference between PMMA and silicone elastomers (p < 0.05), with the silicones exhibiting greater roughness.

Conclusions

The fillers in m-PMMA may inhibit the release of antimicrobial agents. The locally produced m-PMMA demonstrated less microbial adherence in comparison to other tested materials.

Clinical implications

The locally produced m-PMMA was associated with less microbial adherence in comparison to other tested materials and has potential to reduce the risk of infection.

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四种颌面修复材料抗菌性能和表面粗糙度的比较评价

目的微生物附着于颌面部修复材料表面可引起周围组织感染，引起不适、刺激和感染。因此，如果颌面假体材料具有抗菌作用或抵抗微生物粘附是有益的。本研究的目的是比较本地生产的改性聚甲基丙烯酸甲酯颌面假体材料与商业生产的聚甲基丙烯酸甲酯和两种有机硅弹性体对三种微生物的抗菌效果、表面粗糙度和微生物粘附性。方法组成4个研究组，每组10个样品（n = 10）：改性聚甲基丙烯酸甲酯（m-PMMA）、市售聚甲基丙烯酸甲酯（c-PMMA）、硅胶A-2000 （A-2000）和硅胶A-2186 （A-2186）。对4种假体材料检测的微生物分别为金黄色葡萄球菌（S. aureus）、变形链球菌（S. mutans）和白色念珠菌（C. albicans）。评估了抗菌效果、微生物粘附性和表面粗糙度，扫描电子显微镜图像检查了表面粗糙度和微生物粘附性。结果所有材料均未显示出抑菌活性。与PMMA相比，有机硅弹性体上的微生物粘附性明显更高，金黄色葡萄球菌和变形葡萄球菌的集落形成单位都更大（p < 0.017）。在有机硅弹性体和PMMA之间，白色念珠菌粘附性没有显著差异。表面粗糙度分析显示PMMA和有机硅弹性体之间存在统计学差异（p < 0.05），有机硅弹性体表现出更大的粗糙度。结论m-PMMA填充剂可抑制抗菌药物的释放。与其他测试材料相比，本地生产的m-PMMA显示出较少的微生物粘附性。临床意义与其他测试材料相比，本地生产的m-PMMA具有较少的微生物粘附性，具有降低感染风险的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.