Epilepsy and migraine: A bidirectional mendelian randomization study

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-09-26 DOI:10.1016/j.yebeh.2025.110723

Fangliang Chen , Jianyun Sun , Jianxiang Lei , Yu Wang

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Abstract

Objective

Numerous observational research reports have consistently demonstrated a significant association between migraines and epilepsy, but it remains uncertain whether a causal relationship exists between these two diseases. This study aims to explore the potential causal relationship between epilepsy and migraine through a two-sample bidirectional Mendelian randomization (MR) analysis.

Methods

A two-sample bidirectional MR analysis was conducted using the data from the genome-wide association studies (GWAS) of epilepsy and migraine in the European population. The primary analytical approach was the inverse variance weighted (IVW) method, with additional MR methods, including MR-Egger and weighted median, employed for complementary analysis. Comprehensive sensitivity analyses were also performed to assess the robustness of the results.

Results

The MR analysis showed no evidence of a causal relationship between epilepsy and migraine (P > 0.05) in either the forward or reverse analysis. Sensitivity analyses validated the reliability of the results.

Significance

No evidence of a genetic causal relationship between migraine and epilepsy was identified. However, the mechanisms underlying the observed association between the two diseases in observational studies warrant further investigation.

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癫痫和偏头痛：一项双向孟德尔随机研究

众多观察性研究报告一致表明偏头痛和癫痫之间存在显著关联，但这两种疾病之间是否存在因果关系仍不确定。本研究旨在通过双样本双向孟德尔随机化（MR）分析，探讨癫痫与偏头痛之间的潜在因果关系。方法利用欧洲人群癫痫和偏头痛全基因组关联研究（GWAS）数据进行双样本双向MR分析。主要分析方法为逆方差加权（IVW）法，并采用MR- egger和加权中位数等MR方法进行补充分析。还进行了综合敏感性分析以评估结果的稳健性。结果磁共振分析显示癫痫和偏头痛之间没有因果关系（P > 0.05），无论是正向分析还是反向分析。敏感性分析验证了结果的可靠性。意义：没有证据表明偏头痛和癫痫之间存在遗传因果关系。然而，观察性研究中观察到的两种疾病之间关联的机制有待进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.