A Highly Efficient Dual-functional Fluorescent Probe to Sarin and Sulfur Mustard Substitutes

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-09-26 DOI:10.1016/j.snb.2025.138868

Pengfei Shang, Wenjia Tan, Jing Huang, Xin Miao, Wenjing Liu, Guangjuan Liu, Feng Li, Ming Zhang

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Abstract

Chemical warfare agents, particularly nerve agent Sarin and blister agent Sulfur Mustard, are used in warfare and terrorist attacks, severely threatening global security. However, there are few reports on simultaneous gas-phase detection of both using single fluorescent probes, which have high application potential. This study presents a novel dual-functional fluorescent probe BHDTAZ, with dimethyl acridine (DMA) as donor and triazole (TAZ) as acceptor. It shows distinct responses to Sarin simulant diethyl chlorophosphate (DCP) and Sulfur Mustard simulant 2-chloroethyl ethyl sulfide (2-CEES) vapors: DCP induces a photoluminescence (PL) emission intensity ratio (I₅₀₇/I₄₂₈) of 9.3, 79 nm red-shift, and LOD of 1.25 ppb; 2-CEES causes 40% PL enhancement, 12 nm red-shift, and LOD of 1.23 ppm. Notably, naked-eye visible PL color changes occur blue-to-green for DCP, unchanged blue for 2-CEES. Mechanistic studies reveal that modulated intermolecular charge transfer (ICT) effect enables differentiation, with DCP enhancing it more potently. This work provides dual-functional probe for gas-phase identification of the simulants and advances PL-based multiplex chemical threat detection strategies.

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沙林和芥子气替代品的高效双功能荧光探针

化学战剂，特别是神经毒剂沙林和起泡剂硫磺芥末，被用于战争和恐怖袭击，严重威胁着全球安全。然而，利用单个荧光探针同时进行两者的气相检测的报道很少，具有很高的应用潜力。以二甲基吖啶（DMA）为供体，三唑（TAZ）为受体，制备了一种新型双功能荧光探针BHDTAZ。它对模拟沙林二乙基氯磷酸（DCP）和模拟硫芥2-氯乙基硫醚（2-CEES）蒸气有明显的响应：DCP诱导光致发光（PL）发射强度比（I507/I428）为9.3，红移为79 nm， LOD为1.25 ppb；2-CEES可使PL增强40%，红移12 nm， LOD为1.23 ppm。值得注意的是，肉眼可见的PL颜色变化为DCP的蓝色到绿色，而2-CEES的蓝色不变。机制研究表明，调制分子间电荷转移（ICT）效应能够促进分化，而DCP更有效地增强了这一效应。这项工作为模拟物的气相识别提供了双功能探针，并推进了基于pl的多重化学威胁检测策略。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.