Interstitial drug delivery system: Physiological basis and (pre)clinical progress

IF 11.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2025-09-26 DOI:10.1016/j.jconrel.2025.114275

Aocan Zhao , Yisi Tang , Xudong Shi , Wufa Fan

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Abstract

The interstitial drug delivery system, with a long-standing history in pharmaceutical science, has recently regained significant attention due to its pivotal role in enhancing drug transport to lymphatic vessels and improving lymph node targeting. The success of mRNA vaccines against SARS-CoV-2 during the COVID-19 pandemic has ushered in a new era for interstitial-based drug delivery strategies. Consequently, advancing the development of next-generation interstitial delivery systems necessitates a deeper understanding of interstitial physiology. This review systematically summarizes the physiological composition and functions of the interstitium, discusses the distinct characteristics of diverse interstitial administration routes, evaluates recent advances in formulation design and clinical translation efforts of advanced delivery systems, and highlights current challenges and future directions in the field. By providing this comprehensive analysis, we aim to stimulate the wider clinical application of interstitial delivery systems in therapeutic practice.

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间质性给药系统的生理基础及研究进展

间质给药系统在制药科学中有着悠久的历史，近年来由于其在促进药物向淋巴管转运和改善淋巴结靶向方面的关键作用而重新受到重视。在COVID-19大流行期间，针对SARS-CoV-2的mRNA疫苗的成功开启了基于间质性药物递送策略的新时代。因此，推进下一代间质传递系统的发展需要对间质生理学有更深入的了解。本文系统地总结了间质的生理组成和功能，讨论了不同间质给药途径的不同特点，评估了先进给药系统的配方设计和临床翻译工作的最新进展，并强调了该领域当前的挑战和未来的方向。通过提供这一全面的分析，我们的目标是促进间质输送系统在治疗实践中更广泛的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.