Sleep stage mixing is associated with poor prognosis in early Parkinson's disease.

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-09-26 DOI:10.1038/s41531-025-01105-w

Pauline Dodet,Emmanuel During,Isabelle Arnulf,Claudia Trenkwalder,Brit Mollenhauer,Friederike Sixel-Döring,Emmanuel Roze,Marie Vidailhet,Thomas Andrillon,Stéphane Lehericy,Jean-Christophe Corvol,Graziella Mangone,Smaranda Leu-Semenescu,Emmanuel Mignot,Poul Jennum,Andreas Brink-Kjaer

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Abstract

This study assessed the prognostic value of probabilistic sleep staging in early PD by quantifying sleep stage uncertainty and mixing. Data from two longitudinal cohorts (DeNoPa and ICEBERG) included 280 patients with early PD (mean duration 21.1 months) and 158 matched controls. Sleep stages were scored automatically using U-Sleep, which provides for each 30-s epoch a probabilistic distribution of wakefulness (W), NREM stage N1, N2, N3, and REM sleep. Uncertainty (percentage of sleep stages with less than 80% certainty) and mixed stages were quantified. PD patients showed higher sleep stage uncertainty and wake-N3 mixing, especially those with REM sleep behavior disorder. Greater W-N3 mixing was associated with worse motor and cognitive scores at baseline and with faster motor decline over time. EEG features of this mixing suggested unstable deep sleep. These findings support the value of automated sleep analysis to detect microstructural sleep disruptions linked to PD progression.

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睡眠阶段混杂与早期帕金森病预后不良相关。

本研究通过量化睡眠阶段不确定性和混合评估概率睡眠阶段对早期PD的预后价值。来自两个纵向队列（DeNoPa和ICEBERG）的数据包括280名早期PD患者（平均持续时间21.1个月）和158名匹配的对照组。使用U-Sleep自动对睡眠阶段进行评分，该评分为每个30秒epoch提供清醒(W)、NREM阶段N1、N2、N3和REM睡眠的概率分布。不确定性（确定性低于80%的睡眠阶段的百分比）和混合阶段被量化。PD患者表现出较高的睡眠阶段不确定性和清醒- n3混淆，尤其是伴有REM睡眠行为障碍的患者。更大的W-N3混合与基线时更差的运动和认知得分以及随着时间的推移更快的运动衰退有关。这种混合的脑电图特征表明不稳定的深度睡眠。这些发现支持了自动化睡眠分析在检测与PD进展相关的微观结构睡眠中断方面的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.