N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum.

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-09-26 DOI:10.1038/s41531-025-01110-z

Emmanouela Leandrou,Ioanna Chalatsa,Kostas Vekrellis,Evangelia Emmanouilidou

引用次数: 0

Abstract

The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.

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n型Ca2+通道介导小鼠纹状体刺激依赖性α-突触核蛋白分泌。

突触前末端α-突触核蛋白的分泌通过钙依赖机制受到神经元活性的控制。为了解决电压门控钙通道在这一过程中的作用，我们使用反向脑微透析来监测α-突触核蛋白在选择性通道抑制剂存在下的体内释放。结果表明，ω- concontoxin对gvia敏感的n型钙通道是刺激小鼠纹状体α-突触核蛋白分泌的主要介质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.