Global inequalities in the burden of traumatic spinal cord injury from 1990 to 2021: findings from the global burden of disease study 2021.

IF 4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroepidemiology Pub Date : 2025-09-25 DOI:10.1159/000548481

Siqiao Wang, Shun Chen, Wenyong Fan, Tao Chen, Xiao Hu, Chen Li, Zhourui Wu, Wei Xu, Zhihui Xiao, Bei Ma, Liming Cheng

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引用次数: 0

Abstract

Instruction: Traumatic spinal cord injury (TSCI) can cause severe health loss because of premature mortality and long-term disabilities. This study estimated the global, regional, and national incidence, prevalence and years lived with disability (YLDs) of TSCI using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Methods: DisMod-MR2.1 was utilized to derive case number and age-standardized rate (ASR) with 95% uncertainty intervals (95% UIs) for the incidence (ASIR), prevalence (ASPR), and YLDs (ASYR) for SCI from 1990 to 2021 for the whole world, 21 GBD regions, and 204 countries. Estimated annual percentage change (EAPC) was determined using a linear regression mode. Spearman rank order correlation was performed to identify the correlations between sociodemographic index (SDI) and the burden of TSCI.

Results: Globally, there were 574,502 (95% UI 440,219 to 757,445) incident cases, 15,400,682 (95% UI, 17,075,106-14,009,114) prevalent cases and 1,305,142 (95% UI, 1,726,419-917,167) YLDs of total TSCI in 2021. From 1990, the number of incidences, prevalence, and YLDs cases showed an upward trend, while the ASIR, ASPR, and ASYR showed a downward trend. Males had higher ASIR, ASPR, and ASYR, and the ASIR, ASPR, and ASYR increased with age. Cervical SCI had higher ASIR and ASYR than SCI below neck level. It showed positive correlations between SDI and ASIR (rho = 0.4670, p < 0.01), ASPR (rho = 0.4035, p < 0.01), and ASYR (rho = 0.2727, p = 0.003) in 2021.

Conclusion: The absolute counts of incidence, prevalence, and burden of TSCI substantially increased from 1990 to 2021, despite the decrease in corresponding ASRs. TSCI happened in the most active periods of individuals globally, which were shifting towards older age groups over time. TSCI had larger effects on the elderly and males than younger populations and females.

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1990年至2021年全球创伤性脊髓损伤负担的不平等：来自2021年全球疾病负担研究的结果

说明：创伤性脊髓损伤（TSCI）可造成严重的健康损失，因为过早死亡和长期残疾。本研究使用来自2021年全球疾病、损伤和风险因素负担研究（GBD）的数据，估计了全球、地区和国家TSCI的发病率、患病率和残疾生活年限（YLDs）。方法：采用DisMod-MR2.1计算1990 - 2021年全球、21个GBD地区和204个国家脊髓损伤的发病率（ASIR）、患病率（ASPR）和年龄标准化率（ASR）的95%不确定区间（95% UIs）。估计年百分比变化（EAPC）采用线性回归模式确定。采用Spearman秩序相关法确定社会人口学指数（SDI）与TSCI负担之间的相关性。结果：在全球范围内，2021年TSCI总病例为574,502例（95% UI, 440,219 ~ 757,445），流行病例为15,400,682例（95% UI, 17,075,106 ~ 14,009,114）， yld为1,305,142例（95% UI, 1,726,419 ~ 917,167）。1990年以来，发病率、患病率和YLDs病例数呈上升趋势，而ASIR、ASPR和ASYR呈下降趋势。男性有较高的ASIR、ASPR和ASYR，且ASIR、ASPR和ASYR随年龄增长而增加。颈段脊髓损伤的ASIR和ASYR均高于颈段以下脊髓损伤。2021年SDI与ASIR （rho = 0.4670, p < 0.01）、ASPR （rho = 0.4035, p < 0.01）、ASYR （rho = 0.2727, p = 0.003）呈正相关。结论：1990年至2021年，TSCI的发病率、患病率和负担的绝对数量大幅增加，尽管相应的asr有所下降。TSCI发生在全球个体最活跃的时期，随着时间的推移，这些个体向老年群体转移。TSCI对老年人和男性的影响大于年轻人群和女性。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.