Lag-structure in fMRI across Three Psychiatric Groups: State-dependency and Clinical-behavioral Correlates.

IF 2.9 3区 医学 Q3 CLINICAL NEUROLOGY
Livio Tarchi, Stefano Damiani, Paolo La-Torraca-Vittori, Giovanni Castellini, Pierluigi Politi, Paolo Fusar-Poli, Valdo Ricca
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Abstract

fMRI measures beyond zero-lag functional connectivity could serve as useful tools for understanding the distinct spatio-temporal dynamics characterizing psychiatric conditions. Therefore, the primary objective was to investigate whether and how state-dependence influences lag-structure in healthy controls (n = 95). Moreover, the study aimed to explore clinical-behavioral correlates of state-dependent lag-structure in three groups of psychiatric patients (35 ADHD, 38 Bipolar Disorder and 23 Schizophrenia patients, diagnosed according to DSM-IV-TR). Lag-structure was computed from cross-correlation coefficients in resting-state and stop-signal scans. Between and within-group differences were compared through non-parametric tests. Correlations with clinical-behavioral parameters were evaluated using linear regressions (Brief Psychiatric Rating Scale - BPRS, task reaction time). Compared to healthy controls, lag-structure within default-mode, executive-control and salience networks was generally increased in ADHD (min Z-score - 3.983), generally decreased in Schizophrenia (min Z-score - 3.716) and mixed increased/decreased in Bipolar patients (min Z-score - 3.912, max 4.739). Widespread state-dependent reductions of lag-structure were observed across all groups from rest to task (max Q-statistics: healthy controls 58; ADHD 22; Bipolar 26; Schizophrenia 17). Correlations with clinical-behavioral features (BPRS, reaction time) were positive in the executive-control network and negative in the bilateral thalamus for ADHD; negative in the cerebellum for Schizophrenia; positive in the right temporal gyri, amygdala, hippocampus, cerebellum for Bipolar Disorder (p = 0.05). In summary, according to these preliminary results, differences in lag-structure in comparison to healthy controls may be described as progressively increased in magnitude from ADHD to Bipolar Disorder and Schizophrenia, with specific clinical and behavioral correlates according to each diagnostic group.

三个精神病组的功能磁共振成像滞后结构:状态依赖性和临床行为相关性。
超越零滞后功能连接的fMRI测量可以作为理解表征精神疾病的独特时空动态的有用工具。因此,本研究的主要目的是研究状态依赖是否以及如何影响健康对照组的滞后结构(n = 95)。此外,本研究旨在探讨三组精神病患者(35例ADHD, 38例双相障碍和23例精神分裂症患者,根据DSM-IV-TR诊断)的状态依赖滞后结构的临床行为相关性。通过静息状态和停止信号扫描的互相关系数计算滞后结构。通过非参数检验比较组间和组内差异。与临床行为参数的相关性采用线性回归评估(简短精神病学评定量表- BPRS,任务反应时间)。与健康对照相比,ADHD患者默认模式、执行控制和显著性网络中的滞后结构普遍增加(最小Z-score - 3.983),精神分裂症患者普遍减少(最小Z-score - 3.716),双相情感障碍患者混合增加/减少(最小Z-score - 3.912,最大4.739)。从休息到任务,所有组都观察到广泛的状态依赖性延迟结构减少(最大q统计:健康对照组58;ADHD 22;躁郁症26;精神分裂症17)。ADHD患者的执行控制网络与临床行为特征(BPRS、反应时间)呈正相关,双侧丘脑与临床行为特征(BPRS、反应时间)呈负相关;精神分裂症的小脑呈阴性;双相情感障碍患者右侧颞回、杏仁核、海马、小脑呈阳性(p = 0.05)。总之,根据这些初步结果,与健康对照组相比,滞后结构的差异可能被描述为从ADHD到双相情感障碍和精神分裂症的程度逐渐增加,根据每个诊断组具有特定的临床和行为相关性。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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