Gut Microbiota in Adults with Chronic Widespread Pain: A Systematic Review.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Diseases (Basel, Switzerland) Pub Date : 2025-09-09 DOI:10.3390/diseases13090299

Pui-Ying Leong, Lin-Hong Shi

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Abstract

Background/objectives: Chronic widespread pain (CWP), a key feature of fibromyalgia (FM), has been increasingly associated with gut microbiota alterations, yet the specific changes in microbial composition and the therapeutic potential of probiotics or prebiotics in these patients remain unclear. This systematic review aimed to synthesize current evidence regarding gut microbiota alterations and the effects of microbiota-targeted interventions in individuals with CWP/FM.

Methods: A comprehensive search across multiple databases, including PubMed, Web of Science, Cochrane Library, Ovid Embase, Medline, Ovid AMED, and Global Health. These studies were categorized into two primary themes: changes in gut microbiota composition at various taxonomic levels and the therapeutic impact of microbiota-involved treatments in patients with CWP/FM.

Results: We finally identified 432 studies, of which 11 met the inclusion criteria. The findings indicate that while alterations in the gut microbiota have been observed in CWP patients, the evidence remains limited and heterogeneous.

Conclusions: Preliminary indications suggest a potential role of dysbiosis in the pathophysiology of CWP, but further rigorously designed studies are needed to clarify the therapeutic efficacy of microbiota-based interventions in this patient population.

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成人慢性广泛性疼痛的肠道菌群：一项系统综述。

背景/目的：慢性广泛性疼痛（CWP）是纤维肌痛（FM）的一个关键特征，已越来越多地与肠道微生物群改变相关，但微生物组成的具体变化以及益生菌或益生元在这些患者中的治疗潜力尚不清楚。本系统综述旨在综合目前关于肠道微生物群改变的证据以及针对微生物群的干预对CWP/FM患者的影响。方法：在多个数据库中进行综合搜索，包括PubMed、Web of Science、Cochrane Library、Ovid Embase、Medline、Ovid AMED和Global Health。这些研究分为两个主要主题：不同分类水平下肠道微生物群组成的变化以及涉及微生物群的治疗对CWP/FM患者的治疗影响。结果：我们最终确定了432项研究，其中11项符合纳入标准。研究结果表明，虽然在CWP患者中观察到肠道微生物群的改变，但证据仍然有限且不均匀。结论：初步适应症表明，生态失调在CWP的病理生理中可能起作用，但需要进一步严格设计的研究来阐明基于微生物群的干预对该患者群体的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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