Chlorogenic Acid and VX765 Alleviate Deoxynivalenol-Induced Enterohepatic Injury and Lipid Metabolism Disorders by Improving Intestinal Microecology.

IF 4 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Toxins Pub Date : 2025-09-18 DOI:10.3390/toxins17090467

Tao Wen, Sirui Li, Huijun Guo, Jinbo Wang, Xinru Zhang, Chunyang Wang

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引用次数: 0

Abstract

Widespread contamination of deoxynivalenol (DON) in cereals and feed threatens global food safety. This study investigated the effects of Chlorogenic acid (CGA) and VX765 on DON-induced enterohepatic injury. A total of 48 female mice were divided into four groups: control (normal saline), DON (1 mg/kg.bw), CGA (100 mg/kg.bw CGA + 1 mg/kg.bw DON), and VX765 (100 mg/kg.bw VX765 + 1 mg/kg.bw DON). After 28-day gavage period, the results showed that CGA and VX765 reduced DON-induced intestinal barrier damage. Metabolomics data revealed that CGA and VX765 restored cecal microbiota structure and alleviated DON-induced hepatic injury and lipid metabolic disorders by reshaping intestinal microbiota. Retrograde endocannabinoid signaling was identified as a critical pathway for cecal microbial metabolism and hepatic lipid regulation mediated by CGA and VX765. Additionally, CGA and VX765 reversed the upregulation of IMPA, CDS2, DGKA, NDUFS8, and MAPK1 mRNA and protein expression levels induced by DON via the microbiota-gut-liver axis.

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绿原酸和VX765通过改善肠道微生态减轻脱氧雪腐酚诱导的肠肝损伤和脂质代谢紊乱。

谷物和饲料中脱氧雪腐菌烯醇（DON）的广泛污染威胁着全球食品安全。本研究探讨绿原酸（CGA）和VX765对don诱导的肠肝损伤的影响。将48只雌性小鼠分为4组：对照组（生理盐水）、DON （1 mg/kg）。CGA （100 mg/kg）。bw CGA + 1mg /kg。bw DON)和VX765 （100 mg/kg）。bw VX765 + 1mg /kg。bw)。灌胃28 d后，CGA和VX765可减轻don诱导的肠屏障损伤。代谢组学数据显示，CGA和VX765通过重塑肠道菌群，恢复盲肠菌群结构，减轻don诱导的肝损伤和脂质代谢紊乱。逆行内源性大麻素信号被认为是CGA和VX765介导的盲肠微生物代谢和肝脏脂质调节的关键途径。此外，CGA和VX765通过微生物-肠-肝轴逆转DON诱导的IMPA、CDS2、DGKA、NDUFS8和MAPK1 mRNA和蛋白表达水平上调。

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来源期刊

Toxins TOXICOLOGY-

CiteScore

7.50

自引率

16.70%

发文量

765

审稿时长

16.24 days

期刊介绍： Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.