m6A methylation - a new target of metabolic diseases induced by environmental pollutants.

IF 4.5 4区医学 Q2 ENVIRONMENTAL SCIENCES

Reviews on Environmental Health Pub Date : 2025-09-26 DOI:10.1515/reveh-2025-0057

Runfeng Chang, Jinyun Li, Lu Fang, Miaocui Xi, Yue Huang, Jiahang Li, Wenjun Zhang, Qiuhui Qian, Zejun Wang, Jin Yan, Huili Wang

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引用次数: 0

Abstract

Exposure to environmental pollutants is closely associated with the development of obesity and related metabolic diseases. As the most prevalent form of eukaryotic chemical modification, N6-methyladenosine (m6A) methylation regulated by series enzymes plays an important role in the pathogenesis of metabolic diseases such as obesity, non-alcoholic fatty liver disease (NAFLD), atherosclerosis (AS), and type 2 diabetes (T2D). Therefore, investigating the specific mechanisms of m6A methylation in obesity and related metabolic diseases and its relationship with environmental pollutants is vital for developing treatment and prevention strategies. This article summarizes the latest research on m6A methylation in glucose and lipid metabolism-related diseases and elucidates the specific molecular mechanisms of metabolic disorders regulated by m6A methylation-related enzymes. More importantly, we highlight that m6A methylation process is a target for environmental pollutants in inducing human metabolic diseases. Our review aims to provide new insights into understanding the underlying mechanisms of environmental pollutant-induced metabolic diseases and to explore preventive and therapeutic measures.

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m6A甲基化——环境污染物诱导代谢性疾病的新靶点

暴露于环境污染物与肥胖及相关代谢疾病的发生密切相关。n6 -甲基腺苷（m6A）甲基化是最常见的真核化学修饰形式，由一系列酶调控，在肥胖、非酒精性脂肪性肝病（NAFLD）、动脉粥样硬化（As）、2型糖尿病（T2D）等代谢性疾病的发病机制中起重要作用。因此，研究m6A甲基化在肥胖及相关代谢性疾病中的具体机制及其与环境污染物的关系，对于制定治疗和预防策略至关重要。本文综述了m6A甲基化在糖脂代谢相关疾病中的最新研究进展，并阐述了m6A甲基化相关酶调控代谢紊乱的具体分子机制。更重要的是，我们强调m6A甲基化过程是环境污染物诱导人类代谢性疾病的靶标。我们的综述旨在为了解环境污染物引起的代谢性疾病的潜在机制提供新的见解，并探索预防和治疗措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews on Environmental Health Social Sciences-Health (social science)

CiteScore

7.20

自引率

2.60%

发文量

期刊介绍： Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment. Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.