Florencia Herbstein, Julieta Reinoso, Nicolas Ciancio Del Giudice, David Gonilski-Pacin, Manuel Fiz, Joaquina Cagliero, Mariana Fuertes, Eduardo Arzt
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引用次数: 0
Abstract
Folliculostellate (FS) cells are non-endocrine cells of the anterior pituitary with roles in local communication, immune-endocrine regulation, and tissue homeostasis. Although they comprise only a small fraction of the gland, FS cells exert paracrine influence on hormone-secreting cells and respond to immune signals, particularly through interleukin-6 (IL-6) production. This review outlines classical and newly described features of FS cells and we also examine their dual role in pituitary tumorigenesis, where they may both promote and restrain tumor growth depending on context. FS cells act as immune sensors, mediating responses to bacterial signals and modulating the hypothalamic-pituitary-adrenal axis during stress and aging. Their potential contribution to inflammaging and tumor progression highlights FS cells as key players in pituitary physiology and pathology and immune-neuroendocrine connections.
期刊介绍：
The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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