Florina Chiscop, Carmen-Cristiana Cazacu, Dragos-Alexandru Cazacu, Costel Emil Cotet
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引用次数: 0
Abstract
This study investigates the thermal properties and sterilization efficacy of polylactic acid (PLA) components fabricated via fused deposition modeling (FDM), focusing on PLA's compatibility with autoclave sterilization protocols. While PLA is extensively recognized for its biobased and biodegradable characteristics, its limited thermal stability has traditionally restricted its application in high-temperature sterilization settings, such as in medical contexts. In our research, we examined three distinct specimen geometries-cylindrical, rectangular, and curved-subjecting them to thermal post-processing through constrained annealing, employing salt or silicone as the embedding medium. Following this process, we exposed the specimens to elevated temperatures, simulating typical sterilization conditions. The outcomes indicated that the annealed PLA specimens exhibited dimensional stability at temperatures exceeding 170 °C, thereby demonstrating their viability for steam sterilization procedures. To translate these findings into practical applications, we selected a small, complex geometrically relevant component, the Easy Bone Collector (EBC) shell, for autoclave testing at 134 °C. Post-sterilization, the part successfully retained its shape and functionality, indicating that, with appropriate thermal conditioning, PLA can be effectively utilized to manufacture cost-efficient, autoclavable components suitable for medical use. These results reveal a promising and sustainable approach to producing reusable, sterilization-compatible PLA devices, particularly in low-volume or single-use applications where biodegradability is advantageous.
本研究研究了通过熔融沉积建模(FDM)制备的聚乳酸(PLA)组件的热性能和灭菌效果,重点研究了PLA与高压灭菌方案的兼容性。虽然聚乳酸因其生物基和可生物降解特性而被广泛认可,但其有限的热稳定性传统上限制了其在高温灭菌环境中的应用,例如在医疗环境中。在我们的研究中,我们检查了三种不同的试样几何形状-圆柱形,矩形和弯曲-通过约束退火对它们进行热后处理,采用盐或硅树脂作为包埋介质。在这个过程中,我们将标本暴露在高温下,模拟典型的灭菌条件。结果表明,退火后的PLA样品在超过170°C的温度下表现出尺寸稳定性,从而证明了它们在蒸汽灭菌过程中的可行性。为了将这些发现转化为实际应用,我们选择了一个小而复杂的几何相关组件,Easy Bone Collector (EBC)外壳,在134°C的高压灭菌器中进行测试。灭菌后,该部件成功地保留了其形状和功能,这表明,通过适当的热调节,PLA可以有效地用于制造适合医疗用途的具有成本效益的、可高压灭菌的部件。这些结果揭示了一种有前途和可持续的方法来生产可重复使用的、灭菌兼容的PLA设备,特别是在生物降解性有利的小批量或一次性应用中。
期刊介绍:
Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.