Dynamic Stability Analysis of Progressive Supranuclear Palsy affected gait using Lyapunov Floquet Theory.

IF 5.2 2区 医学 Q2 ENGINEERING, BIOMEDICAL
Sandesh G Bhat, Farwa Ali, Cecilia A Hogen, Asghar Rezaei, Keith A Josephs, Jennifer L Whitwell, Kenton R Kaufman
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Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disease with severe gait and balance deficits. There are no effective ways to assess dynamic balance during walking in PSP. The Lyapunov Floquet (LF) theory has been utilized to study dynamic balance in healthy and pathologic gait but has not been applied to PSP affected gait. In the current study, the medio-lateral motion of the center of mass during gait for 40 patients with PSP (PSP group) and 33 healthy older adults (Control group) were studied. Metrics from LF theory, such as the maximal Floquet multiplier (FM), maximal long-term Lyapunov Exponent (LEL), and maximal short-term Lyapunov Exponent (LES) were used to study walking stability. Although all the gait dynamics for all the participants were stable and non-chaotic, the PSP group was observed to be closer to an unstable system and more susceptible to perturbations (|FM| closer to 1 and LEL closer to 0) than the Control group (p < 0.001). The control group's stability deteriorated, and the gait system became more susceptible to perturbations with age. Such a trend was not observed in the PSP group. The risk of falls increased with increase in cadence in the PSP group (p < 0.001). These findings demonstrate the potential of LF theory measures to evaluate dynamic stability in patients with PSP and the need for future research using quantitative measures.

利用Lyapunov Floquet理论分析进行性核上性麻痹对步态影响的动态稳定性。
进行性核上性麻痹(PSP)是一种伴有严重步态和平衡缺陷的神经退行性疾病。目前尚无有效的方法来评估PSP患者行走时的动态平衡。Lyapunov Floquet (LF)理论已被用于研究健康和病理步态的动态平衡,但尚未应用于PSP影响的步态。本研究对40例PSP患者(PSP组)和33例健康老年人(对照组)的步态中质心的中外侧运动进行了研究。采用最大Floquet乘数(FM)、最大长期Lyapunov指数(LEL)和最大短期Lyapunov指数(LES)等LF理论指标来研究步行稳定性。尽管所有参与者的步态动力学都是稳定且非混沌的,但观察到PSP组比对照组更接近于不稳定系统,更容易受到扰动(|FM|接近1,LEL接近0)(p < 0.001)。对照组的稳定性恶化,步态系统随着年龄的增长变得更容易受到干扰。在PSP组中没有观察到这种趋势。在PSP组中,跌倒的风险随着节奏的增加而增加(p < 0.001)。这些发现证明了LF理论测量在评估PSP患者动态稳定性方面的潜力,以及未来使用定量测量进行研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.60
自引率
8.20%
发文量
479
审稿时长
6-12 weeks
期刊介绍: Rehabilitative and neural aspects of biomedical engineering, including functional electrical stimulation, acoustic dynamics, human performance measurement and analysis, nerve stimulation, electromyography, motor control and stimulation; and hardware and software applications for rehabilitation engineering and assistive devices.
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