Sustainable Durian Rind Carboxymethyl Cellulose/Poly(vinyl) Alcohol Hydrogels Synthesis for Enhancing Crosslinking and Release Kinetics Efficiency.

IF 5.3 3区化学 Q1 POLYMER SCIENCE

Gels Pub Date : 2025-09-11 DOI:10.3390/gels11090728

Kanticha Pratinthong, Rangsan Panyathip, Sarinthip Thanakkasaranee, Kittisak Jantanasakulwong, Wirongrong Tongdeesoontorn, Duangjai Noiwan, Thomas Karbowiak, Chitsiri Rachtanapun, Pornchai Rachtanapun

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引用次数: 0

Abstract

This study developed hydrogels from durian rind-derived carboxymethyl cellulose (CMC_d) blended with poly(vinyl) alcohol (PVA) for biomedical applications. The influence of NaOH concentration (10-60% w/v) on the degree of substitution (DS) of CMC_d and the crosslinking properties of the resulting hydrogels was examined. Durian rind, a biodegradable and renewable resource, was transformed into CMC_d with DS values ranging from 0.17 to 0.94. The highest yield (230.96%) was achieved using 30% NaOH (CMC_d-30). This CMC_d-30 was combined with PVA and crosslinked using citric acid to form a hydrogel with maximum crosslinking efficiency (86.16%). The resulting CMC_d-30/PVA hydrogel exhibited a high swelling ratio (125.54%), reflecting its superior water absorption and functional group availability-key traits for biomedical use. Methylene blue (MB) release from the hydrogel extended up to 1440 min, confirming its drug delivery potential. Overall, the CMC_d-30/PVA hydrogel demonstrated promising biocompatibility potential and performance, making it a promising candidate for wound dressings and controlled drug delivery systems. This work highlights the potential of agricultural waste valorization in developing sustainable and efficient biomaterials for pharmaceutical and medical applications.

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可持续榴莲皮羧甲基纤维素/聚乙烯醇水凝胶的合成及其释放动力学研究

本研究将榴莲皮衍生的羧甲基纤维素（CMCd）与聚乙烯醇（PVA）混合制成生物医学用途的水凝胶。考察了NaOH浓度（10 ~ 60% w/v）对CMCd取代度（DS）和所制水凝胶交联性能的影响。将可降解的可再生资源榴莲皮转化为CMCd，其DS值在0.17 ~ 0.94之间。30% NaOH （CMCd-30）的收率最高，为230.96%。该CMCd-30与PVA结合，用柠檬酸交联，形成交联效率最高的水凝胶（86.16%）。所得的CMCd-30/PVA水凝胶具有较高的溶胀率（125.54%），反映了其优越的吸水性和功能基团有效性，这是生物医学应用的关键特性。亚甲基蓝（MB）从水凝胶的释放延长至1440分钟，证实了其给药潜力。总的来说，CMCd-30/PVA水凝胶具有良好的生物相容性和性能，使其成为伤口敷料和控制药物输送系统的有希望的候选者。这项工作突出了农业废物增值在开发用于制药和医疗应用的可持续和高效生物材料方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.