Global burden of chronic liver disease due to NAFLD from 2012 to 2021: A trend, decomposition, and health inequality analysis.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-09-25 DOI:10.1186/s13098-025-01932-0

Yanrui Wu, Zongbiao Tan, Zhou Liu, Yupei Liu, Chuan Liu, Junhai Zhen, Jixiang Zhang, Weiguo Dong

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引用次数: 0

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is considered to be an important driver of the increasing burden of chronic liver disease (CLD) worldwide. It is necessary to analyze the burden of CLD due to NAFLD (CLD-NAFLD) systematically.

Methods: Data related to CLD-NAFLD burden from 2012 to 2021 were obtained from the Global Burden of Disease Study (GBD) 2021. The temporal trend of the incidence and disability-adjusted life years (DALYs) was quantified by average annual percentage change (AAPC). The driving factors of the incidence/DALYs change were explored through decomposition analysis. Slope index and concentration index were employed to investigate cross-country health inequalities.

Results: During 2012-2021, the global age-standardized incidence rate (ASIR) of CLD-NAFLD increased from 551.52 to 592.78 (per 100,000 population), while the age-standardized DALY rate (ASDR) decreased from 31.92 to 30.90 (per 100,000 population). North Africa and Middle East had the highest age-standardized prevalence rate (ASPR), East Asia experienced the most rapid increase in ASIR, and Caribbean exhibited the most substantial increase in ASDR. Decomposition analysis showed that the main factors driving the increase in incident cases were population growth and epidemiologic changes, whereas population aging and population growth were the main driving factors for the increase of DALYs. There was cross-country health inequality in the DALYs, which showed a decreasing trend from 2012 to 2021. However, the health inequality in incidence was not significant.

Conclusions: The burden of CLD-NAFLD continues to increase. Health policy makers must develop corresponding strategies for the primary health care of metabolic diseases.

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2012 - 2021年NAFLD导致的全球慢性肝病负担：趋势、分解和健康不平等分析

背景：非酒精性脂肪性肝病（NAFLD）被认为是世界范围内慢性肝病（CLD）负担增加的重要驱动因素。有必要对NAFLD造成的CLD负担进行系统分析。方法：从2021年全球疾病负担研究（GBD）中获得2012年至2021年CLD-NAFLD负担相关数据。用平均年百分比变化（AAPC）量化发病率和伤残调整生命年（DALYs）的时间趋势。通过分解分析，探讨了发病率/DALYs变化的驱动因素。采用坡度指数和浓度指数对跨国健康不平等进行调查。结果：2012-2021年，CLD-NAFLD的全球年龄标准化发病率（ASIR）从551.52上升到592.78（每10万人），而年龄标准化DALY率（ASDR）从31.92下降到30.90（每10万人）。北非和中东地区的年龄标准化患病率（asr）最高，东亚地区的ASIR增长最快，加勒比地区的ASDR增长最为显著。分解分析表明，人口增长和流行病学变化是导致病例增加的主要因素，而人口老龄化和人口增长是导致伤残调整生命年增加的主要因素。DALYs存在跨国健康不平等，2012年至2021年呈下降趋势。然而，发病率的健康不平等并不显著。结论：CLD-NAFLD患者负担持续加重。卫生政策制定者必须为代谢性疾病的初级卫生保健制定相应的战略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.