Joint-level proprioceptive deficits and postural instability in Fibromyalgia: a biomechanical assessment using digital inclinometry and dynamic posturography.

IF 4.8 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1622679

Praveen Kumar Kandakurti, Ravi Shankar Reddy, Hani Hassan Alnakhli, Batool A Alkhamis, Ghada M Koura, Mohammad A ALMohiza, Faisal M Alyazedi, Debjani Mukherjee, Vikram Sreenivasa Rao

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Abstract

Objective: Fibromyalgia syndrome (FMS) is characterized by chronic musculoskeletal pain, fatigue, and sensory disturbances, often leading to impaired proprioception and postural control. This study aimed to examine joint reposition sense (JRS) at the hip, knee, and ankle, alongside limits of stability (LOS), in elderly individuals with FMS using digital inclinometers and computerized posturography.

Methods: A total of 108 participants (54 with FMS, 54 age-matched healthy controls) were assessed. JRS was assessed at standardized joint angles of the hip (60° flexion), knee (45° flexion), and ankle (15° plantarflexion) using calibrated digital inclinometers, while LOS parameters-reaction time, maximum excursion, and directional control-were recorded with dynamic posturography.

Results: Participants with FMS showed significantly higher joint position errors at the hip (mean difference = 2.53°), knee (2.51°), and ankle (2.24°) (p < 0.001, Cohen's d > 1.8). LOS parameters were also impaired in the FMS group, with slower reaction time (Δ = 0.97 s), reduced maximum excursion (Δ = -3.44%), and lower directional control (Δ = -22.64%) (all p < 0.001). JRS errors negatively correlated with LOS metrics, particularly at the hip and knee. Regression analysis confirmed JRS as a significant predictor of postural control.

Conclusion: Lower limb proprioceptive deficits significantly impact postural stability in individuals with FMS. Targeted proprioceptive training, especially at the hip and knee, may improve functional balance and reduce fall risk in this population.

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纤维肌痛症关节水平本体感觉缺陷和姿势不稳定：使用数字倾斜测量和动态姿势照相的生物力学评估。

目的：纤维肌痛综合征（FMS）以慢性肌肉骨骼疼痛、疲劳和感觉障碍为特征，常导致本体感觉和姿势控制受损。本研究旨在利用数字倾斜仪和计算机体位术检测老年FMS患者髋关节、膝关节和踝关节的关节复位感（JRS）以及稳定性极限（LOS）。方法：对108名参与者（54名FMS患者，54名年龄匹配的健康对照）进行评估。JRS采用校准的数字倾斜仪对髋关节（60°屈曲）、膝关节（45°屈曲）和踝关节（15°跖屈）的标准化关节角度进行评估，而LOS参数——反应时间、最大偏移和方向控制——则通过动态体位仪记录。结果：FMS患者在髋关节（平均差值为2.53°）、膝关节（平均差值为2.51°）和踝关节（平均差值为2.24°）的关节位置误差显著较高（p < 0.001, Cohen’s d值为1.8）。FMS组的LOS参数也受到损害，反应时间变慢（Δ = 0.97 s），最大偏移量减少（Δ = -3.44%），方向性控制降低（Δ = -22.64%）（均p < 0.001）。JRS误差与LOS指标呈负相关，特别是在髋关节和膝关节。回归分析证实JRS是体位控制的显著预测因子。结论：下肢本体感觉缺陷显著影响FMS患者的姿势稳定性。有针对性的本体感觉训练，特别是在髋关节和膝关节，可以改善功能平衡，减少跌倒的风险。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.