Enhancing LDD diagnosis with YOLOv9-AID: simultaneous detection of pfirrmann grading, disc herniation, HIZ, and Schmorl's nodules.

IF 4.8 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1626299
Erling Xiang, Yongkang Zou, Jiale Chen, Jian Peng, Chunhai Huang, Feiwen Li, Xiaoping Li, Shenghua Qin, Zhiyu Li, Nanyu Li, Xu Zhou, Mingzheng Zhang
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引用次数: 0

Abstract

This study develops an intelligent diagnostic model for LDD based on a novel YOLOv9-AID detection network and evaluates the impact of multiple innovative strategies on detection performance. A total of 222 adult patients who underwent lumbar MRI for low back pain or radicular leg pain were enrolled, yielding 1110 de-identified sagittal T2-weighted images (five per case). After excluding cases with prior spinal trauma, tumors, postoperative changes, congenital malformations, or severe artefacts, 202 cases (1,010 images) were randomly divided into training, validation, and internal test sets (8:1:1), while 20 cases (100 images) formed an external dataset for generalization assessment. The YOLOv9-AID model introduces three key enhancements to the baseline YOLOv9: a SlideLoss function to rebalance training weights between high- and low-quality samples; spatial-channel collaborative attention modules (SCSA) embedded at layers 5 and 11 to strengthen lesion feature extraction; and an ExtraDW-inspired redesign of the ResNCSPELAN4 module to boost precision and reduce parameter count. In the internal test set, the model achieved an mAP50 of 82.8% and an overall detection precision of 80.3%, with Schmorl's node detection at 92.9%, Pfirrmann grading accuracy at 93.3%, and disc herniation accuracy at 73.2% (an 8.4% improvement). Recall rates increased by approximately 5% on average, with Schmorl's node recall up 15.1%, Pfirrmann recall up 1.8%, and herniation recall improvements of up to 12.3%. External validation confirmed robust generalization, and detection rates for small lesions such as high-intensity zones and Schmorl's nodes significantly outperformed conventional methods. These results demonstrate that the YOLOv9-AID network, through the integration of SlideLoss and spatial-channel attention mechanisms, substantially enhances the accuracy and robustness of LDD detection on MRI and offers a promising tool to support clinical diagnosis efficiency and consistency.

Abstract Image

Abstract Image

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YOLOv9-AID增强LDD诊断:同时检测pfirrmann分级、椎间盘突出、HIZ和Schmorl结节。
本研究开发了一种基于新型YOLOv9-AID检测网络的LDD智能诊断模型,并评估了多种创新策略对检测性能的影响。共纳入222名因腰痛或腿根性疼痛接受腰椎MRI检查的成年患者,产生1110张未识别的矢状t2加权图像(每例5张)。在排除既往脊柱创伤、肿瘤、术后改变、先天性畸形或严重伪影后,202例(1010张图像)随机分为训练集、验证集和内部测试集(8:1:1),20例(100张图像)组成外部数据集进行泛化评估。YOLOv9- aid模型引入了基线YOLOv9的三个关键增强:slidelloss功能,用于在高质量和低质量样本之间重新平衡训练权重;在第5层和第11层嵌入空间通道协同注意模块(SCSA),加强病灶特征提取;以及对ResNCSPELAN4模块的重新设计,以提高精度并减少参数计数。在内部测试集中,该模型的mAP50为82.8%,整体检测精度为80.3%,其中Schmorl节点检测准确率为92.9%,Pfirrmann分级准确率为93.3%,椎间盘突出准确率为73.2%,提高了8.4%。召回率平均提高了约5%,其中Schmorl’s node的召回率提高了15.1%,Pfirrmann的召回率提高了1.8%,疝的召回率提高了12.3%。外部验证证实了鲁棒泛化,并且对于小病变(如高强度区和Schmorl's淋巴结)的检出率明显优于传统方法。这些结果表明,YOLOv9-AID网络通过整合SlideLoss和空间通道注意机制,大大提高了MRI LDD检测的准确性和鲁棒性,为支持临床诊断效率和一致性提供了一个有前途的工具。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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