Relationship between benzene concentration, MDA levels and kidney function in car painting workshops in Surabaya: A cross-sectional observational study.

Q2 Pharmacology, Toxicology and Pharmaceutics

F1000Research Pub Date : 2025-09-05 eCollection Date: 2023-01-01 DOI:10.12688/f1000research.140287.3

Abdul Rohim Tualeka, Mohd Yusmaidie Aziz, Velu Perumal, Tamilanban Thamaraikani, Roslan Rosnon, Salsabila Novianti, Pudji Rahmawati, Ahsan Ahsan

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引用次数: 0

Abstract

Background: Car painting workers are at risk of health problems, particularly kidney disorders, due to exposure to solvents containing benzene as the main ingredient in the car painting process. Therefore, the purpose of this study is to analyze the relationship between benzene and Risk Quotient (RQ) benzene concentrations with Malondialdehyde (MDA), Blood Urea Nitrogen (BUN), and creatinine levels in workers exposed to benzene in car painting workshops in Surabaya.

Methods: This study used an observational design with a cross-sectional method conducted at two car paint workshops in Surabaya. The study population was all workers exposed to benzene in the two car paint workshops, aged between 20-65 years in 2019. The sample was taken using an random sampling method, involving 30 respondents. Inclusion criteria included workers exposed to benzene and willing to participate, while exclusion criteria included workers with a liver or kidney disease history. The variables studied included benzene concentration, benzene RQ (benzene metabolite), malondialdehyde (MDA) levels as a marker of oxidative stress, and indicators of kidney function (BUN and creatinine levels). Data were analyzed using descriptive and bivariate analysis with Pearson correlation test.

Results: There was no significant relationship between concentrations, RQ benzene, and MDA levels in workers in painting in Surabaya (p> 0.05). There was no significant relationship between benzene concentration, BUN levels, and creatinine levels in paint workers in Surabaya (p> 0.05). There was no significant relationship between benzene RQ and BUN and creatinine levels in paint workers in Surabaya (p> 0.05).

Conclusions: This study's results indicate that benzene's effects do not lead to impaired kidney function. The benzene RQ variable in this study did not become a determining factor in BUN and creatinine levels in workers.

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泗水汽车喷漆车间苯浓度、丙二醛水平与肾功能的关系：一项横断面观察研究。

背景：汽车喷漆工人面临健康问题，特别是肾脏疾病的风险，因为在汽车喷漆过程中暴露于含苯的溶剂中。因此，本研究的目的是分析苯与风险商（RQ）之间的关系，苯浓度与丙二醛（MDA）、血尿素氮（BUN）和肌酐水平在泗水汽车喷漆车间暴露于苯的工人。方法：本研究采用观察性设计，采用横断面法在泗水的两个汽车涂料车间进行。研究人群是2019年在两个汽车油漆车间接触苯的所有工人，年龄在20-65岁之间。本研究采用随机抽样方法，共30人。纳入标准包括接触苯并愿意参与的工人，而排除标准包括有肝脏或肾脏疾病史的工人。研究的变量包括苯浓度、苯RQ（苯代谢物）、丙二醛（MDA）水平（氧化应激的标志）和肾功能指标（BUN和肌酐水平）。数据分析采用描述性和双变量分析，Pearson相关检验。结果：泗水地区彩绘工人苯浓度、RQ、丙二醛水平无显著相关性（p < 0.05）。泗水市涂料工人苯浓度、BUN水平和肌酐水平之间无显著相关性（p < 0.05）。泗水市涂料工人苯RQ、BUN和肌酐水平无显著相关性（p < 0.05）。结论：本研究结果表明苯的作用不会导致肾功能损害。本研究中苯RQ变量并没有成为工人BUN和肌酐水平的决定性因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

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