Orodispersible film based on hyaluronic acid and morin for dental biofilm control.

IF 2 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biofouling Pub Date : 2025-09-26 DOI:10.1080/08927014.2025.2560090

Lorena Fonseca Piovesan, Marina de Lima Fontes, Milena da Silva Gimenes, Saulo Duarte Ozelin, Gustavo Claro Monteiro, Jhonatan Miguel Silva, Maciel Lima Barbosa, Fernanda Lourenção Brighenti, Hernane da Silva Barud

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引用次数: 0

Abstract

Orodispersible films (ODFs) are an innovative oral drug delivery method benefiting pediatric, geriatric, and non-compliant patients. They are portable, easy to swallow, and enhance bioavailability. Hyaluronic acid (HA) stands out among hydrophilic polymers for oral delivery of antimicrobial agents. This study evaluated the physicochemical properties, in vitro release profile, and antimicrobial/antibiofilm activity of HA-based ODFs combined with the flavonoid morin, known for its antimicrobial properties. Antimicrobial activity and microbial viability were assessed via biomass quantification. The films were thin (12-27 µm), flexible, homogeneous, and mechanically resistant. A burst release of morin was observed, reaching complete release at 210 min. Cytotoxicity analysis confirmed the non-toxic profile, showing cell viability. HA-morin films significantly reduced Streptococcus mutans biofilm mass, viability, and acidogenicity compared to the controls. Findings confirmed the non-toxic, and their significant antibiofilm activity against S. mutans. This innovative mucoadhesive system has potential for managing dental diseases and oral drug delivery.

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基于透明质酸和桑里素的口腔生物膜分散膜控制。

口服分散膜（odf）是一种创新的口服给药方法，有利于儿童，老年人和非依从性患者。它们携带方便，易于吞咽，并提高生物利用度。透明质酸（HA）在抗菌剂口服递送的亲水性聚合物中脱颖而出。本研究评估了ha基odf与类黄酮桑里酮（以其抗菌特性而闻名）联合的理化性质、体外释放谱和抗菌/抗生物膜活性。通过生物量定量评价其抑菌活性和微生物活力。薄膜薄（12-27µm），柔韧，均匀，耐机械。观察到morin的突然释放，在210 min达到完全释放。细胞毒性分析证实了其无毒特征，显示细胞活力。与对照组相比，HA-morin膜显著降低了变形链球菌的生物膜质量、活力和致酸性。结果证实其无毒，且具有显著的抗变形链球菌活性。这种创新的黏合剂系统在管理口腔疾病和口服药物输送方面具有潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biofouling 生物-海洋与淡水生物学

CiteScore

5.00

自引率

7.40%

发文量

审稿时长

1.7 months

期刊介绍： Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion. Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context. Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.