Min Li, Bo Liu, Man Yuan, Xiaoli Dai, Shuang Qiu, Xiangkui Zhang, Xiaoyang Zheng, Kai Chen, Chonggang Duan, Daizhou Zhang, Dongliang Wang, Xiangjing Meng
{"title":"Morphological and histopathological study of edible bird’s nest on wound healing in mice","authors":"Min Li, Bo Liu, Man Yuan, Xiaoli Dai, Shuang Qiu, Xiangkui Zhang, Xiaoyang Zheng, Kai Chen, Chonggang Duan, Daizhou Zhang, Dongliang Wang, Xiangjing Meng","doi":"10.1007/s10735-025-10581-6","DOIUrl":null,"url":null,"abstract":"<div><p>Edible bird’s nest (EBN) has a variety of pharmacological effects, such as improving immunity, antioxidant, promoting brain development, nerve prevention, degenerative diseases, and whitening and moisturizing skin, but its role in wound healing is still unknown. In this study, full-thickness excisional wounds were made on the back of mice to establish the wound model. The mice were treated with EBN, a positive drug, and 0.9% NaCl for 14 days. At days 3, 7, and 14 post-injury, the traumatic skin and intestinal contents of mice were collected. ELISA, western blot and quantitative PCR assay were used to evaluate the expression of inflammatory factor, protein, and mRNA. The damaged skin of the mice was analyzed by histopathology. Biochemical experiment was used to evaluate the content of hydroxyproline. Gas chromatograph was used to detect mouse intestinal contents. Results showed that EBN can narrow the wound area, reduce the expression of inflammatory factors, upregulate the expression of collagen and α-SMA, improve the damaged skin structure, increase the content of SCFAs and promote wound recovery rapidly. Current findings may suggest that EBN might serve as a potential effective substance for wound healing therapy either orally or externally.</p></div>","PeriodicalId":650,"journal":{"name":"Journal of Molecular Histology","volume":"56 5","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10735-025-10581-6.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Histology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10735-025-10581-6","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Edible bird’s nest (EBN) has a variety of pharmacological effects, such as improving immunity, antioxidant, promoting brain development, nerve prevention, degenerative diseases, and whitening and moisturizing skin, but its role in wound healing is still unknown. In this study, full-thickness excisional wounds were made on the back of mice to establish the wound model. The mice were treated with EBN, a positive drug, and 0.9% NaCl for 14 days. At days 3, 7, and 14 post-injury, the traumatic skin and intestinal contents of mice were collected. ELISA, western blot and quantitative PCR assay were used to evaluate the expression of inflammatory factor, protein, and mRNA. The damaged skin of the mice was analyzed by histopathology. Biochemical experiment was used to evaluate the content of hydroxyproline. Gas chromatograph was used to detect mouse intestinal contents. Results showed that EBN can narrow the wound area, reduce the expression of inflammatory factors, upregulate the expression of collagen and α-SMA, improve the damaged skin structure, increase the content of SCFAs and promote wound recovery rapidly. Current findings may suggest that EBN might serve as a potential effective substance for wound healing therapy either orally or externally.
期刊介绍:
The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes.
Major research themes of particular interest include:
- Cell-Cell and Cell-Matrix Interactions;
- Connective Tissues;
- Development and Disease;
- Neuroscience.
Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance.
The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.