A decade of progress in transition metal-catalyzed sulfoxide reductions.

IF 3.8 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2025-09-25 DOI:10.1007/s11030-025-11346-9

Mohammad Abu Shuheil, Radwan Ali, Munthar Kadhim Abosaoda, M M Rekha, Mosstafa Kazemi, Subhashree Ray, Kattela Chennakesavulu, Renu Sharma

引用次数: 0

Abstract

The deoxygenation of sulfoxides to sulfides is a fundamental reaction in organic synthesis, widely used in pharmaceuticals, materials science, and natural product chemistry. Traditional methods require stoichiometric reagents under harsh conditions, but transition metal catalysis now allows milder, more selective, and environmentally friendly deoxygenation. This review highlights recent advances in catalytic systems based on Mo, Ir, Mn, Co, and other metals, focusing on their mechanisms, substrate scopes, and sustainable design. Innovations in recyclable catalysts, green solvents, earth-abundant metals are also discussed, emphasizing how modern approaches enhance both efficiency and environmental compatibility.

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过渡金属催化亚砜还原的十年进展。

亚砜脱氧为硫化物是有机合成中的基本反应，广泛应用于制药、材料科学和天然产物化学等领域。传统的方法需要在恶劣条件下的化学计量试剂，但过渡金属催化现在允许更温和，更具选择性和环保的脱氧。本文综述了基于Mo、Ir、Mn、Co和其他金属的催化体系的最新进展，重点介绍了它们的机制、底物范围和可持续设计。还讨论了可回收催化剂、绿色溶剂、富含地球资源的金属等方面的创新，强调了现代方法如何提高效率和环境相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;