Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers.

IF 6.6 2区 化学 Q1 SPECTROSCOPY
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello
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引用次数: 0

Abstract

The review examines the evolution of chemical ionization mass spectrometry (CI-MS), a technique developed in 1966 by Field and Munson. CI is a soft-ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI). CI-MS is widely utilized across various fields, including atmospheric chemistry, environmental science, and biomedical research. The article highlights different CI-MS types, such as proton transfer reaction mass spectrometry (PTR-MS), which is renowned for its ability to analyze volatile organic compounds in real-time; negative ion CI-MS, which provides insights into anions; selected ion flow tube mass spectrometry (SIFT-MS), and ion-drift chemical ionization mass spectrometry (ID-CIMS), techniques that allow for the direct analysis of trace gases with high sensitivity and specificity. The article discusses advancements in chromatography with CI-MS, particularly atmospheric pressure chemical ionization (APCI) and liquid electron ionization (LEI) interface. The ongoing exchange of data between fundamental ion/molecule studies and specific applications has significantly boosted the growth of CI-MS in recent decades. In recent years, no extensive review has been published on CI-MS. This article provides an overview of CI-MS technique, its applications, and its evolution over the years, highlighting its importance in advancing scientific research and understanding the chemistry of various environments.

化学电离质谱:基本原理,不同的应用,和最新的技术前沿。
本文回顾了化学电离质谱法(CI-MS)的发展,这是Field和Munson于1966年开发的一种技术。CI是一种软电离方法,它比电子电离(EI)产生更强的分子离子,碎片化更小。CI-MS被广泛应用于各个领域,包括大气化学、环境科学和生物医学研究。文章重点介绍了不同的CI-MS类型,如质子转移反应质谱(PTR-MS),它以其实时分析挥发性有机化合物的能力而闻名;负离子CI-MS,可以深入了解阴离子;选择性离子流管质谱法(SIFT-MS)和离子漂移化学电离质谱法(ID-CIMS),这些技术可以直接分析具有高灵敏度和特异性的微量气体。本文讨论了CI-MS在色谱分析方面的研究进展,特别是常压化学电离(APCI)和液体电子电离(LEI)界面。近几十年来,基础离子/分子研究和特定应用之间的持续数据交换极大地促进了CI-MS的发展。近年来,CI-MS并没有广泛的综述。本文概述了CI-MS技术及其应用及其多年来的发展,强调了其在推进科学研究和理解各种环境化学方面的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mass Spectrometry Reviews
Mass Spectrometry Reviews 物理-光谱学
CiteScore
16.30
自引率
3.00%
发文量
56
期刊介绍: The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.
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