Magdiel Inggrid Setyawati, Bernice Huan Rong Goh, Archana Gautam, Darien Yu De Kwek, Choon Teck Low, Samuel Vernon Jing Heng Ong, Ee Cherk Cheong, Kee Woei Ng
{"title":"Engineered Nanomaterials at Physiologically Relevant Doses Promote Keratinocyte Migration via Induction of Autophagy- and Redox-Dependent Pathways.","authors":"Magdiel Inggrid Setyawati, Bernice Huan Rong Goh, Archana Gautam, Darien Yu De Kwek, Choon Teck Low, Samuel Vernon Jing Heng Ong, Ee Cherk Cheong, Kee Woei Ng","doi":"10.1021/acsami.5c15035","DOIUrl":null,"url":null,"abstract":"<p><p>The proliferating incorporation of engineered nanomaterials (ENMs) in everyday consumer products, such as sunscreen, poses concerns about the dermal exposure effects of these ENMs. Well-characterized ENMs, titanium dioxide and zinc oxide, are utilized as models to understand ENM interactions with skin cells and their influence on wound closure. The ENMs, at relevant exposure doses, have been demonstrated to promote the wound closure process in both <i>in vitro</i> and <i>ex vivo</i> skin explant models. Mechanistic studies reveal that the wound closure process is modulated by intracellular ROS production, with the involvement of autophagy, JNK, and ERK signaling pathways, to promote ENM-induced focal adhesion turnover, microtubule remodeling, and cell migration.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":""},"PeriodicalIF":8.2000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsami.5c15035","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The proliferating incorporation of engineered nanomaterials (ENMs) in everyday consumer products, such as sunscreen, poses concerns about the dermal exposure effects of these ENMs. Well-characterized ENMs, titanium dioxide and zinc oxide, are utilized as models to understand ENM interactions with skin cells and their influence on wound closure. The ENMs, at relevant exposure doses, have been demonstrated to promote the wound closure process in both in vitro and ex vivo skin explant models. Mechanistic studies reveal that the wound closure process is modulated by intracellular ROS production, with the involvement of autophagy, JNK, and ERK signaling pathways, to promote ENM-induced focal adhesion turnover, microtubule remodeling, and cell migration.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
