Xinyang Du, Hongyi Gu, Xinyi Ouyang, Zhiyang Ma, Hailong Guo, Rui Li, Xudong Yao, Yingchun Zhu, Xiaozhao Wang
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引用次数: 0
Abstract
Articular cartilage defects, caused by trauma or degenerative changes, pose significant challenges due to the restricted self-repair capability of the cartilage tissues. Current clinical treatments, such as autologous transplantation and microfracture surgery, often fail to achieve complete restoration of functionality. Advanced 3D bioprinting technology offers a promising strategy by facilitating the precise construction of biomimetic scaffolds. This review examines the application of 3D bioprinting in cartilage regeneration, emphasizing the key technologies such as inkjet, extrusion, stereolithography, and digital-light-processing printing, alongside advancements in material innovations involving synthetic, natural, and composite polymers. It discusses strategies for optimizing scaffold design, including pore structure, mechanical properties, and bioactive factor integration. The review also examines monophasic, biphasic, and gradient scaffolds, emphasizing their potential to mimic native tissue hierarchies and improve repair outcomes. Despite advancements, challenges, including long-term efficacy, mechanical stability, and clinical translation, remain. Future research should emphasize interdisciplinary collaboration to advance bioink formulation, printing precision, and scalable manufacturing, ultimately enhancing cartilage regeneration therapies.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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