Yttrium-90 Selective Internal Radiotherapy for Gastrointestinal Stromal Tumor With Liver Metastasis: A Case Report and Review

Abstract

Gastrointestinal stromal tumors (GISTs), the most prevalent mesenchymal neoplasms of the gastrointestinal tract, frequently metastasize to the liver. Despite this clinical reality, there is a lack of standardized therapeutic protocols for GIST liver metastases (GISTLM). Here we present the first case of a GISTLM patient treated with Yttrium-90 (Y90) resin microsphere selective internal radiation therapy (SIRT) in China. We further reviewed the current challenges in GISTLM management and highlighted the emerging role of SIRT. By integrating case-specific insights with broader therapeutic paradigms, we aim to develop safe and effective individualized treatment strategies for GIST patients.