P. C. Nagajyothi, Kuruvalli Gouthami, Subhasish Maity, K. Pavani, Clement Okraku Tettey, Vaddi Damodara Reddy, Jaesool Shim
{"title":"Antibacterial and Anticancer Activity of Ag-CeO2 Nanocomposite","authors":"P. C. Nagajyothi, Kuruvalli Gouthami, Subhasish Maity, K. Pavani, Clement Okraku Tettey, Vaddi Damodara Reddy, Jaesool Shim","doi":"10.1007/s10876-025-02829-8","DOIUrl":null,"url":null,"abstract":"<div><p><i>In this study</i>,<i> Foeniculum vulgare</i> seed-mediated AgNPs were deposited onto the surface of MOF-derived CeO₂. The structural, elemental, chemical, functional, and morphological properties of the Ag-CeO₂ NC were characterized using XRD, EDX, FTIR, SEM, and HR-TEM techniques. XRD results indicate the presence of AgNPs and CeO₂ NPs in the composite. FTIR studies revealed seven different functional groups in the composite. SEM and TEM results indicate the spherical-shaped AgNPs are well distributed on the CeO₂ flakes. EDS analysis confirms the presence of Ce, Ag, and O in the synthesized composite. Ag-CeO₂ nanocomposite exhibited significant antibacterial activity against <i>S. aureus</i>, <i>P. aeruginosa</i>, <i>B. substilis</i>, and <i>E. coli</i>. The minimum inhibitory concentration (MIC) values were achieved at concentrations of 60–80 µg/mL, with optimal activity observed at 80 µg/mL, resulting in zone of clearance values of 10.23 ± 0.46 mm against <i>Staphylococcus aureus</i>, 6.09 ± 0.13 mm against <i>Pseudomonas aeruginosa</i>, 11.29 ± 0.39 mm against <i>Bacillus subtilis</i> and 11.25 ± 0.45 mm against <i>E. coli</i>. These results suggest that the Ag-CeO₂ nanocomposite has potential as an effective antibacterial agent. Furthermore, the anticancer potential of the Ag-CeO<sub>2</sub> NC was assessed on MCF-7 human breast cancer cells. The MTT assay showed that cell viability decreased with increasing Ag-CeO₂ NC concentrations, ranging from 2.5 to 50 µg/mL. Overall, the synthesized Ag-CeO<sub>2</sub> NC demonstrates promise as an effective agent against bacterial infections and cancer cell proliferation.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-025-02829-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, Foeniculum vulgare seed-mediated AgNPs were deposited onto the surface of MOF-derived CeO₂. The structural, elemental, chemical, functional, and morphological properties of the Ag-CeO₂ NC were characterized using XRD, EDX, FTIR, SEM, and HR-TEM techniques. XRD results indicate the presence of AgNPs and CeO₂ NPs in the composite. FTIR studies revealed seven different functional groups in the composite. SEM and TEM results indicate the spherical-shaped AgNPs are well distributed on the CeO₂ flakes. EDS analysis confirms the presence of Ce, Ag, and O in the synthesized composite. Ag-CeO₂ nanocomposite exhibited significant antibacterial activity against S. aureus, P. aeruginosa, B. substilis, and E. coli. The minimum inhibitory concentration (MIC) values were achieved at concentrations of 60–80 µg/mL, with optimal activity observed at 80 µg/mL, resulting in zone of clearance values of 10.23 ± 0.46 mm against Staphylococcus aureus, 6.09 ± 0.13 mm against Pseudomonas aeruginosa, 11.29 ± 0.39 mm against Bacillus subtilis and 11.25 ± 0.45 mm against E. coli. These results suggest that the Ag-CeO₂ nanocomposite has potential as an effective antibacterial agent. Furthermore, the anticancer potential of the Ag-CeO2 NC was assessed on MCF-7 human breast cancer cells. The MTT assay showed that cell viability decreased with increasing Ag-CeO₂ NC concentrations, ranging from 2.5 to 50 µg/mL. Overall, the synthesized Ag-CeO2 NC demonstrates promise as an effective agent against bacterial infections and cancer cell proliferation.
期刊介绍:
The journal publishes the following types of papers: (a) original and important research;
(b) authoritative comprehensive reviews or short overviews of topics of current
interest; (c) brief but urgent communications on new significant research; and (d)
commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
disciplines.