Temperature-Dependent Solubility and Thermodynamic Behavior of Glibenclamide in 1-Propanol/2-Propanol and Propylene Glycol Mixtures

Abstract

In this study, the solubility of glibenclamide was examined in binary solvent mixtures of 1-propanol/2-propanol and propylene glycol mixtures at temperatures between 298.2 K and 313.2 K. The solubility values were measured using a shake-flask method, with concentrations determined using a UV–Vis spectrophotometer. In these mixtures, the lowest solubility of glibenclamide was observed in neat PG at with solubility increasing as the temperature rises. Also, the highest solubility was recorded at the 1-propanol/2-propanol mass fraction of 0.6 and 0.5 and solubility increases with increasing temperature. The obtained solubility data were correlated by mathematical models, including the van’t Hoff, Jouyban–Acree, Jouyban–Acree–van’t Hoff, mixture response surface, and modified Wilson models and results showed high accuracy with low MRDs% (< 3.5%). Moreover, the density values for saturated mixtures were measured and represented by the Jouyban–Acree model with MRD% of 0.2 for both systems. The experimental data for glibenclamide dissolution at different temperatures can be used for computation of the thermodynamic properties, such as ΔG°, ΔH°, ΔS°, and TΔS°. These properties provide important insights into the energetic aspects of the dissolution process and were calculated using the van’t Hoff and Gibbs equations.