Usage of 3D-Printed Scaffolds Manufactured with Bio-Based Photopolymer Resin Via 3D DLP in Tissue Engineering

IF 5 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2025-05-15 DOI:10.1007/s10924-025-03592-7

Özge Tezel, Memet Vezir Kahraman, Ramazan Ceylan, Ayşegül Açıksarı, Ebru Demir, Sibel Çetinel

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引用次数: 0

Abstract

In this study, three-dimensional (3D) printed scaffolds were fabricated using a bio-based photopolymer resin derived from sustainable resources for tissue engineering applications. The resin consisted of a UV-curable bio-based fatty acid-based polyester acrylate, polyethylene glycol dimethacrylate, and a photoinitiator. To enhance porosity and biodegradability, coconut oil and poly(ethylene glycol) (PEG) were incorporated into the formulations. The curing behavior of different formulations was investigated by differential photocalorimetry (Photo-DSC), and it was observed that polyethylene glycol accelerated the curing process. The biocompatibility of the 3D printed scaffolds was evaluated using culture experiments with mouse fibroblast (L-929) cells. The obtained results demonstrate that the developed bio-based photopolymer resins have the potential to be a promising material for tissue engineering applications.

Graphical Abstract

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生物基光聚合物树脂3D打印支架在组织工程中的应用

在这项研究中，三维（3D）打印支架是用生物基光聚合物树脂制成的，该树脂来源于可持续资源，用于组织工程应用。该树脂由可紫外光固化的生物基脂肪酸基聚酯丙烯酸酯、聚乙二醇二甲基丙烯酸酯和光引发剂组成。为了提高孔隙度和生物降解性，在配方中加入了椰子油和聚乙二醇（PEG）。采用差示光量热法（photodsc）研究了不同配方的固化行为，发现聚乙二醇加速了固化过程。采用小鼠成纤维细胞（L-929）培养实验评价3D打印支架的生物相容性。研究结果表明，所制备的生物基光聚合物树脂具有成为组织工程材料的潜力。图形抽象

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.