Prospects for the Application of Synthetic Zeolites as Components of Wound Coverings and Selective Hemosorbents

Abstract

The issues of potential applicability of synthetic framework aluminosilicates (zeolites) as components of medical materials are considered. The physicochemical characteristics, moisture capacity and sorption capacity in relation to model toxins of protein nature of synthetic zeolites of several structural types (Beta, Rho, Y, and paulingite) differing in their chemical composition, porosity, and methods of production were studied. The hemolytic activity and cytotoxicity in relation to human Ea.hy926 line endothelial cells were studied. It was established that synthetic zeolites have a high moisture capacity and selective sorption capacity in relation to model protein preparations in the medium of a synthetic biological fluid. Zeolites exhibit the largest sorption capacity in relation to low molecular weight proteins that are a basis of intoxication of the organism during wound, burn, and other lesions. A toxicity of zeolites is determined by their chemical composition and the conditions for their production. Among the studied zeolites, the zeolite Y can be recommended for the use as a component of wound coverings and other medical materials as a nontoxic, highly efficient selective sorbent.