Box–Behnken Optimized Sustained-Release PEG-PLGA Nanoparticles for Enhanced Cytotoxicity of Resveratrol Against Gastric Cancer Cells

IF 3.6 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Cluster Science Pub Date : 2025-06-14 DOI:10.1007/s10876-025-02851-w

Mengting Wu, Jiang Xia, Yang Hu, Hui Song, Wenlan Li, Wenjun Zhang

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引用次数: 0

Abstract

Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, posing significant therapeutic challenges due to its aggressive nature and limited treatment efficacy. Resveratrol (Res), a natural polyphenol, has demonstrated promising anti-gastric cancer properties by inducing apoptosis, inhibiting proliferation, and suppressing metastasis. However, its clinical application is hindered by poor water solubility and low physicochemical stability. To improve and maintain the anti-gastric cancer activity and stability of Res, this study developed a novel sustained-release nano formulation of resveratrol using polyethylene glycol–poly (lactic-co-glycolic acid) (PEG-PLGA) as a nanocarrier. The formulation was optimized via a Box–Behnken design to enhance drug encapsulation efficiency and control release kinetics. Compared with free resveratrol, Res-PEG-PLGA nanoparticles exhibited sustained release for nearly 10 hours. Furthermore, MTT assays demonstrated that Res-PEG-PLGA nanoparticles significantly enhanced the cytotoxicity and growth inhibition of resveratrol against SGC-7901 gastric cancer cells. This innovative approach offers a promising strategy for enhancing the therapeutic efficacy of resveratrol in gastric cancer treatment.

Graphical Abstract

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Box-Behnken优化的缓释PEG-PLGA纳米颗粒增强白藜芦醇对胃癌细胞的细胞毒性

胃癌仍然是全球癌症相关死亡的主要原因之一，由于其侵袭性和有限的治疗效果，给治疗带来了重大挑战。白藜芦醇（Resveratrol, Res）是一种天然多酚，具有诱导细胞凋亡、抑制增殖和抑制转移等抗胃癌作用。但其水溶性差、理化稳定性低，阻碍了其临床应用。为了提高和维持白藜芦醇的抗胃癌活性和稳定性，本研究以聚乙二醇-聚乳酸-共乙醇酸（PEG-PLGA）为纳米载体，开发了一种新型的白藜芦醇纳米缓释制剂。通过Box-Behnken设计优化处方，提高药物包封效率和控制释放动力学。与游离白藜芦醇相比，Res-PEG-PLGA纳米颗粒具有近10小时的缓释作用。此外，MTT实验表明，Res-PEG-PLGA纳米颗粒显著增强了白藜芦醇对SGC-7901胃癌细胞的细胞毒性和生长抑制作用。这种创新的方法为提高白藜芦醇在胃癌治疗中的疗效提供了一种有希望的策略。图形抽象

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.