Abeer Mogadem, Awatif Rashed Z. Almotairy, Mostafa El-Khatib, Passant A. Ismail, Bassma H. Elwakil
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引用次数: 0
Abstract
Potent Magnesium-Carbon Fullerene nanocomposite was created by a plasma reactor that vaporizes the Magnesium anode, and carbon cathode in the dielectric media (distilled water) by applying a powerful electric field between them. The Magnesium-Carbon Fullerene nanocomposite was characterized to examine its stability, shape, size, and crystal phase structure. Characterization analysis such as High Resolution Transmission Electron Microscope (HR-TEM), X-Ray Diffraction (XRD), Zeta potential, Fourier-transform infrared (FTIR), and Energy Dispersive X-ray (EDX) confirmed that the Synthesized Magnesium-Carbon Fullerene nanocomposite was successfully prepared with the nano with average polygonal Mg particle diameter 35 ± 5 nm combined with carbon nano sheets with − 24.1 mv zetapotential indicating high stability. The 50% cell cytotoxic concentration equaled 201.85 ± 3.94 µg/ml. The synthesized yield showed a potent antibacterial effect against the test microbes, reaching 150 µg/ml minimum inhibitory concentration against Staphylococcus aureus while completely eradicating the bacterial growth after 20 h of incubation. Moreover, Magnesium-Carbon Fullerene had a surprisingly high anti-inflammatory effect. Notably, Mg@C Fullerene nanocomposite demonstrated pronounced and specific inhibition of COX-2, with an IC50 of 0.092 µM and a SI of 135.86.
期刊介绍:
The journal publishes the following types of papers: (a) original and important research;
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commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
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