Synthesized Mg@C Fullerene Nanocomposite Using a Plasma Reactor and its Biological Activity

IF 3.6 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR
Abeer Mogadem, Awatif Rashed Z. Almotairy, Mostafa El-Khatib, Passant A. Ismail, Bassma H. Elwakil
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引用次数: 0

Abstract

Potent Magnesium-Carbon Fullerene nanocomposite was created by a plasma reactor that vaporizes the Magnesium anode, and carbon cathode in the dielectric media (distilled water) by applying a powerful electric field between them. The Magnesium-Carbon Fullerene nanocomposite was characterized to examine its stability, shape, size, and crystal phase structure. Characterization analysis such as High Resolution Transmission Electron Microscope (HR-TEM), X-Ray Diffraction (XRD), Zeta potential, Fourier-transform infrared (FTIR), and Energy Dispersive X-ray (EDX) confirmed that the Synthesized Magnesium-Carbon Fullerene nanocomposite was successfully prepared with the nano with average polygonal Mg particle diameter 35 ± 5 nm combined with carbon nano sheets with − 24.1 mv zetapotential indicating high stability. The 50% cell cytotoxic concentration equaled 201.85 ± 3.94 µg/ml. The synthesized yield showed a potent antibacterial effect against the test microbes, reaching 150 µg/ml minimum inhibitory concentration against Staphylococcus aureus while completely eradicating the bacterial growth after 20 h of incubation. Moreover, Magnesium-Carbon Fullerene had a surprisingly high anti-inflammatory effect. Notably, Mg@C Fullerene nanocomposite demonstrated pronounced and specific inhibition of COX-2, with an IC50 of 0.092 µM and a SI of 135.86.

等离子体反应器合成Mg@C富勒烯纳米复合材料及其生物活性
有效的镁-碳富勒烯纳米复合材料是由等离子体反应器产生的,通过在镁阳极和碳阴极之间施加一个强大的电场,使它们在电介质(蒸馏水)中蒸发。表征了镁碳富勒烯纳米复合材料的稳定性、形状、尺寸和晶相结构。通过高分辨率透射电镜(HR-TEM)、x射线衍射(XRD)、Zeta电位、傅里叶变换红外(FTIR)和能量色散x射线(EDX)等表征分析,证实了镁-碳富勒烯纳米复合材料的制备成功,其平均多边形Mg颗粒直径为35±5 nm, Zeta电位为- 24.1 mv,具有较高的稳定性。50%细胞毒浓度为201.85±3.94µg/ml。合成产物对实验微生物有较强的抑菌作用,对金黄色葡萄球菌的最低抑菌浓度达到150µg/ml,培养20 h后可完全根除细菌生长。此外,镁碳富勒烯具有惊人的高抗炎作用。值得注意的是,Mg@C富勒烯纳米复合材料对COX-2具有明显的特异性抑制作用,IC50为0.092µM, SI为135.86。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
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