Multifunctional Bioactive Facial Mask Fabricated Composite Nanofibers Filled with Paeonia Lactiflora Polysaccharide Exhibiting Effective Cell Proliferation

Abstract

Patch facial mask has many advantages of moisturizing and hydrating, but it also has some disadvantages of removing residues after use and wasting essence. In order to fabricate a new type of facial mask with biological activity, a composite nanofiber membranes was designed and constructed using electrospinning technology, consisting of hydrophilic polymer polyvinyl alcohol(PVA), hydrophobic polymer polylactic acid (PLA), and Paeonia lactiflora polysaccharide (PLP). The fiber membrane was characterized using scanning electron microscopy (SEM), infrared spectroscopy, and thermogravimetric analysis. The spun fiber membrane exhibited good water absorption and retention capabilities, a rapid in vitro release rate, excellent1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and 2,2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging abilities, and certain antibacterial properties. The PLP, PVA/PLA spun membrane was able to maintain the antioxidant and antibacterial activities of PLP while also possessing excellent moisture retention properties. Cell experiments demonstrated that the prepared electrospun nanofiber facial mask is safe and particularly capable of promoting cell proliferation. This composite fiber membrane provides a good basis for green and safe facial masks.

Graphical abstract