Double network hydrogel based on PVA and CMC: synthesis and its potential application in local drug delivery

IF 2.3 4区 化学 Q3 CHEMISTRY, PHYSICAL
Hanieh Javaheri, Hossein Ghasemzadeh, Abolfazl Keshtkar Vanashi
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引用次数: 0

Abstract

Local drug delivery systems are capable of concentrating optimal doses of drugs to the target regions without affecting healthy tissues. Hydrogels have extensive applications in tissue regeneration, treating diseases, and drug delivery and have recently been employed in localized drug delivery. In the present study, a novel thermo-sensitive double network hydrogel (DNH) was prepared based on polyvinyl alcohol (PVA) and carboxy methyl cellulose (CMC). The formation of the hydrogel was studied using Fourier transform infrared spectrometry (FT-IR), thermogravimetric analysis (TGA), and swelling test. Scanning electron microscopy (FE-SEM) and Brunauer–Emmett–Teller (BET) analysis were used to investigate the morphology and the pore size of the hydrogel, respectively. The tensile test was also performed to determine the amount of stretch and the fracture point of the DNH. The tensile strength of the DNH was found to be 24.7795 kPa. In the next step, a complex of doxorubicin with Fe2+ (Dox-Fe2+) was prepared, and the formation of the complex was investigated by FT-IR and UV–Vis spectroscopy. The release profile of the complex from DNH was studied at various pH and temperatures. The results confirmed the sustained and temperature-dependent release of doxorubicin complex. The kinetic studies of drug release by the DNH showed that the release of Dox-Fe2+ complex follows the Korsmeyer-Peppas model.

基于PVA和CMC的双网络水凝胶的合成及其在局部给药中的潜在应用
局部药物输送系统能够在不影响健康组织的情况下将最佳剂量的药物集中到目标区域。水凝胶在组织再生、疾病治疗和药物递送方面有着广泛的应用,最近被用于局部药物递送。本文以聚乙烯醇(PVA)和羧甲基纤维素(CMC)为原料,制备了一种新型热敏双网水凝胶(DNH)。采用傅里叶红外光谱(FT-IR)、热重分析(TGA)和溶胀试验研究了水凝胶的形成过程。采用扫描电镜(FE-SEM)和布鲁诺尔-埃米特-泰勒(BET)分析分别对水凝胶的形貌和孔径进行了研究。同时进行拉伸试验,确定DNH的拉伸量和断裂点。DNH的抗拉强度为24.7795 kPa。下一步,制备了阿霉素与Fe2+的配合物(Dox-Fe2+),并通过FT-IR和UV-Vis光谱研究了配合物的形成。研究了该配合物在不同pH和温度下的释放曲线。结果证实了阿霉素复合物的持续和温度依赖性释放。DNH对药物释放的动力学研究表明,Dox-Fe2+复合物的释放符合Korsmeyer-Peppas模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Colloid and Polymer Science
Colloid and Polymer Science 化学-高分子科学
CiteScore
4.60
自引率
4.20%
发文量
111
审稿时长
2.2 months
期刊介绍: Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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