Neurovascular coupling is preserved in the cerebral cortex of diabetic mice: A longitudinal study.

IF 4.5
Pei-Pei Chiang, Amy R Nippert, Eric A Newman
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Abstract

Neurovascular coupling (NVC), which mediates transient increases in blood flow to increased neuronal activity, is markedly reduced in the retinas of diabetic patients and in animal models of diabetes. It is unclear, however, whether NVC is similarly reduced in the diabetic brain, as previous studies have yielded conflicting results. We investigated this question by simultaneously monitoring the responses of neurons and adjacent penetrating arterioles to whisker stimulation in the Akita mouse model of type 1 diabetes. We found that NVC, as quantified by two independent analytical techniques, remained constant in Akita mice as diabetes progressed and did not differ from aged-matched control mice. Although NVC, as measured by peak vascular dilation, remained constant, the dilation was more prolonged in 27-33 compared to 11-20 weeks of age (WOA) Akita mice, leading to an enhancement of the blood flow increase. NVC remained constant in control mice between age groups and the basal diameter of penetrating arterioles in both control and Akita mice did not vary between 11 and 33 WOA.

糖尿病小鼠的大脑皮层保留了神经血管耦合:一项纵向研究。
神经血管耦合(NVC)介导短暂的血流量增加以增加神经元活动,在糖尿病患者和糖尿病动物模型的视网膜中显着减少。然而,目前尚不清楚NVC是否在糖尿病大脑中也同样减少,因为之前的研究得出了相互矛盾的结果。我们通过同时监测秋田1型糖尿病小鼠模型中神经元和邻近穿透性小动脉对须刺激的反应来研究这个问题。我们发现,通过两种独立的分析技术量化,随着糖尿病的进展,秋田小鼠的NVC保持不变,与年龄匹配的对照小鼠没有差异。尽管通过血管扩张峰值测量的NVC保持不变,但与11-20周龄(WOA)秋田小鼠相比,27-33周龄的扩张时间更长,导致血流量增加。对照组小鼠的NVC在不同年龄组之间保持不变,在11 - 33 WOA之间,对照组小鼠和秋田小鼠穿透性小动脉的基底直径没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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