Ali Amini, Saeid Heidari-Soureshjani, Catherine Mt Sherwin, Shahrzad Habibi Ghahfarrokhi
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引用次数: 0
Abstract
Introduction: Menopause is known as a stage in a woman's natural life cycle in which menstrual periods permanently stop with developing age. This review aims to review the modulating mechanistic effects of resveratrol (RSV) on cardiometabolic changes associated with menopause.
Methods: To identify published studies before January 12, 2025, a comprehensive search was conducted across various electronic databases, such as Web of Science, PubMed/MEDLINE, Embase, Scopus, and the Cochrane Library. Based on the study's objectives, two reviewers independently performed data extraction to ensure accuracy and reduce bias. The extracted data were subsequently reviewed.
Results: RSV has reductive effects on blood pressure, improves endothelial function, and enhances insulin-stimulated glucose uptake. It also decreases fasting blood glucose levels, insulin levels, total cholesterol, triglycerides, and adipocyte hypertrophy. Increased estradiol levels correlate with improved cerebrovascular function and enhanced neurovascular coupling. However, the effects on body weight, body mass index (BMI), and lipid metabolism are inconsistent; some studies reported reductions in fat volume and changes in thermogenesis-related gene expression. Moreover, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels increase. While RSV demonstrates potential benefits for vascular function and metabolic regulation, further research is necessary to determine its long-term efficacy.
Discussion: The findings align with existing evidence on RSV's vascular and metabolic benefits, underscoring its complementary therapeutic potential. Limitations, like bioavailability, differences in patient characteristics, and inconsistent lipid outcomes, call for standardized and long-term studies.
Conclusion: RSV, as a phytoestrogen, increases estrogen levels in the intervention groups. RSV shows potential effects in modulating the most studied menopausal cardio-metabolic changes.
引言：更年期是女性自然生命周期中的一个阶段，随着年龄的增长，月经周期永久停止。本文旨在综述白藜芦醇（resveratrol， RSV）对绝经期心脏代谢变化的调节机制。方法：为了确定2025年1月12日之前发表的研究，对各种电子数据库进行了全面的检索，如Web of Science、PubMed/MEDLINE、Embase、Scopus和Cochrane Library。根据研究目标，两名审稿人独立进行数据提取，以确保准确性并减少偏差。随后对提取的数据进行了审查。结果：RSV具有降低血压、改善内皮功能、促进胰岛素刺激的葡萄糖摄取的作用。它还能降低空腹血糖水平、胰岛素水平、总胆固醇、甘油三酯和脂肪细胞肥大。雌二醇水平升高与脑血管功能改善和神经血管耦合增强相关。然而，对体重、体重指数（BMI）和脂质代谢的影响并不一致；一些研究报告了脂肪量的减少和产热相关基因表达的变化。此外，总抗氧化能力（TAC）和丙二醛（MDA）水平升高。虽然RSV对血管功能和代谢调节有潜在的益处，但需要进一步的研究来确定其长期疗效。讨论：这些发现与RSV血管和代谢益处的现有证据一致，强调了其补充治疗潜力。局限性，如生物利用度、患者特征差异和不一致的脂质结果，需要标准化和长期研究。结论：RSV作为一种植物雌激素，可使干预组雌激素水平升高。RSV在调节绝经期心脏代谢变化方面显示出潜在的影响。
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