Preliminary evaluation of a cognitive rehabilitation intervention for post-COVID-19 cognitive impairment: A pilot randomized controlled trial.

IF 1.9 3区心理学 Q4 NEUROSCIENCES

Neuropsychological Rehabilitation Pub Date : 2025-09-24 DOI:10.1080/09602011.2025.2552154

Jacqueline H Becker, Eric Watson, Nadia Zubair, Fernando Carnavali, Emilia Bagiella, David Reich, Juan P Wisnivesky

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引用次数: 0

Abstract

Background: Despite the profound impact of "brain fog" and/or cognitive impairment in relatively young people with Long COVID, no interventions with demonstrated efficacy are currently available. We conducted a pilot randomized controlled trial investigating the preliminary outcomes of a cognitive rehabilitation (CR) intervention adapted for persons with post-COVID cognitive impairment.

Methods: Participants were ≥18 years of age, English-speaking, had history of SARS-CoV-2, and had cognitive impairment on objective measures. Eligible participants were randomized to a 12-week CR intervention or a time - and attention-matched control arm. Objective and subjective cognitive functioning was assessed at pre - and within 2-weeks post-intervention, utilizing validated neuropsychological measures across multiple domains. We compared pre vs. post intervention changes in cognitive scores in intervention vs. control groups.

Results: The mean change in the intervention group compared to the controls in measures of processing speed, learning, memory, language, and of executive function did not reach the threshold for futility. In comparison to controls, the intervention group self-reported significant improvements in cognitive functioning.

Conclusions: We found that an adapted CR intervention for Long COVID may improve post-COVID cognitive impairment in comparison to a time - and attention-matched control group and should be evaluated in a larger trial.

Trial registration: ClinicalTrials.gov identifier: NCT05498493. Registered on 08/10/2022.

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认知康复干预对covid -19后认知障碍的初步评价：一项随机对照试验

背景：尽管“脑雾”和/或认知障碍对相对年轻的长冠肺炎患者产生了深远影响，但目前尚无证明有效的干预措施。我们进行了一项随机对照试验，调查适用于covid后认知障碍患者的认知康复（CR）干预的初步结果。方法：参与者年龄≥18岁，会说英语，有SARS-CoV-2病史，客观测量有认知障碍。符合条件的参与者被随机分配到12周CR干预组或时间和注意力匹配的对照组。在干预前和干预后2周内评估客观和主观认知功能，利用跨多个领域的有效神经心理学测量。我们比较了干预组和对照组在干预前和干预后认知评分的变化。结果：与对照组相比，干预组在处理速度、学习、记忆、语言和执行功能方面的平均变化没有达到无效的阈值。与对照组相比，干预组自我报告认知功能有显著改善。结论：我们发现，与时间和注意力匹配的对照组相比，长期COVID的适应性CR干预可能改善COVID后认知障碍，应在更大规模的试验中进行评估。试验注册：ClinicalTrials.gov标识符：NCT05498493。于2022年8月10日注册。

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来源期刊

Neuropsychological Rehabilitation 医学-神经科学

CiteScore

6.30

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： Neuropsychological Rehabilitation publishes human experimental and clinical research related to rehabilitation, recovery of function, and brain plasticity. The journal is aimed at clinicians who wish to inform their practice in the light of the latest scientific research; at researchers in neurorehabilitation; and finally at researchers in cognitive neuroscience and related fields interested in the mechanisms of recovery and rehabilitation. Papers on neuropsychological assessment will be considered, and special topic reviews (2500-5000 words) addressing specific key questions in rehabilitation, recovery and brain plasticity will also be welcomed. The latter will enter a fast-track refereeing process.