Nerve Fiber Bundle Damage in Spinocerebellar Degeneration on Diffusion Tensor Imaging.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hong-Xin Jiang, Yan-Mei Ju, Guo-Min Ji, Ting-Ting Gao, Yan Xu, Shu-Man Han, Lei Cao, Jin-Xu Wen, Hui-Zhao Wu, Bulang Gao, Wen-Juan Wu
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引用次数: 0

Abstract

Introduction: This study aimed to investigate nerve fiber bundle damage associated with spinocerebellar degeneration, a dominant inherited neurological disorder, using magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI).

Methods: Four cases of spinocerebellar degeneration and ten matched healthy subjects were retrospectively enrolled. DTI software was used for processing and analysis.

Results: All patients had an abnormal spinocerebellar ataxia (SCA) type 3 gene mutation, with cerebellar and brainstem atrophy, a decreased signal in the pons and projection fibers. Significant interruption and destruction were revealed in the midline of the cerebellar peduncle, cerebellar arcuate fibers, and the spinothalamic and spinocerebellar tracts. Significant (p <0.05) decreases were detected in FA values in the cerebellar peduncle (0.51±0.04 vs. 0.68±0.02), cerebellar arcuate fibers (0.37±0.08 vs. 0.51±0.05), spinothalamic tract (0.42±0.03 vs. 0.49±0.05), and spinocerebellar tract (0.44±0.06 vs. 0.52±0.06) compared with healthy controls. Compared with healthy controls, significant (p <0.05) increases were detected in ADC values in the cerebellar peduncle (0.84±0.11 vs. 0.67±0.03), cerebellar arcuate fibers (0.87±0.12 vs. 0.66±0.05), spinothalamic tract (0.89±0.13 vs. 0.70±0.03) within the brainstem, and spinocerebellar tract (0.79±0.07 vs. 0.69±0.06).

Discussion: The MRI DTI technique provides sufficient information for studying spinocerebellar degeneration and for conducting further research on its etiology and diagnosis. Some limitations were present, including the retrospective and single-center study design, a limited patient sample, and enrollment of only Chinese patients.

Conclusion: The MRI DTI technique can clearly demonstrate the degree of damage to nerve fiber bundles in the cerebellum and the adjacent relationship between the fiber bundles entering and exiting the cerebellum in patients with spinocerebellar degeneration.

弥散张量成像对脊髓小脑变性神经纤维束损伤的影响。
简介:本研究旨在利用磁共振成像(MRI)和弥散张量成像(DTI)研究脊髓小脑变性(一种显性遗传性神经系统疾病)相关的神经纤维束损伤。方法:回顾性分析4例脊髓小脑变性患者和10例匹配的健康人。采用DTI软件进行处理和分析。结果:所有患者均有异常的脊髓小脑共济失调(SCA) 3型基因突变,伴有小脑和脑干萎缩,脑桥和投射纤维信号降低。小脑脚中线、小脑弓状纤维、脊髓丘脑束和脊髓小脑束均有明显的中断和破坏。意义(p)讨论:MRI DTI技术为脊髓小脑变性的研究及进一步的病因和诊断研究提供了充分的信息。存在一些局限性,包括回顾性和单中心研究设计,患者样本有限,仅入组中国患者。结论:MRI DTI技术能清晰显示脊髓小脑变性患者小脑神经纤维束的损伤程度及进出小脑纤维束的邻近关系。
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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