Impact of Celiac Artery Stenosis on Pancreatic Fistula Incidence after Pancreatoduodenectomy.

IF 1.1 4区 医学 Q3 SURGERY
Mert Guler, Omer Akay, Husnu Sevik, Ibrahim Taskin Rakici, Ceyda Turan Bektas, Rabia Kucukarslan, Mert Mahsuni Sevinc, Ufuk Oguz Idiz
{"title":"Impact of Celiac Artery Stenosis on Pancreatic Fistula Incidence after Pancreatoduodenectomy.","authors":"Mert Guler, Omer Akay, Husnu Sevik, Ibrahim Taskin Rakici, Ceyda Turan Bektas, Rabia Kucukarslan, Mert Mahsuni Sevinc, Ufuk Oguz Idiz","doi":"10.1177/10926429251382789","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Celiac artery stenosis (CAS) may exacerbate postoperative complications by impairing arterial perfusion in upper abdominal organs. This study evaluated the prevalence of CAS in patients undergoing pancreaticoduodenectomy and its association with clinically significant postoperative pancreatic fistula (POPF). <b><i>Methods:</i></b> A retrospective analysis of 151 patients who underwent pancreaticoduodenectomy between 2017 and 2022 was conducted. CAS was assessed via preoperative computed tomography with a stenosis threshold of ≥50%. Multivariate logistic regression identified risk factors for POPF. <b><i>Results:</i></b> CAS ≥50% was observed in 17.2% of patients, and Grade B/C POPF occurred in 17.9%. In patients with a CAS ≥50%, the risk of POPF was significantly increased (Odds Ratio: 16.458, 95% Confidence Interval: 4.575-59.203, <i>P</i> < .001). A pancreatic duct diameter of less than 3 mm and a soft pancreatic texture were found to be associated with POPF in the univariate analysis (<i>P</i> = .029, <i>P</i> = .032, respectively). Additionally, the prevalence of smoking and the median age were higher in patients with a CAS ≥50 (respectively, <i>P</i> = .011 and <i>P</i> = .052). <b><i>Conclusions:</i></b> CAS is an independent risk factor for clinically significant POPF. Preoperative CAS identification and management are vital to minimizing postoperative complications. Further studies are needed to confirm these findings.</p>","PeriodicalId":50166,"journal":{"name":"Journal of Laparoendoscopic & Advanced Surgical Techniques","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Laparoendoscopic & Advanced Surgical Techniques","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10926429251382789","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Celiac artery stenosis (CAS) may exacerbate postoperative complications by impairing arterial perfusion in upper abdominal organs. This study evaluated the prevalence of CAS in patients undergoing pancreaticoduodenectomy and its association with clinically significant postoperative pancreatic fistula (POPF). Methods: A retrospective analysis of 151 patients who underwent pancreaticoduodenectomy between 2017 and 2022 was conducted. CAS was assessed via preoperative computed tomography with a stenosis threshold of ≥50%. Multivariate logistic regression identified risk factors for POPF. Results: CAS ≥50% was observed in 17.2% of patients, and Grade B/C POPF occurred in 17.9%. In patients with a CAS ≥50%, the risk of POPF was significantly increased (Odds Ratio: 16.458, 95% Confidence Interval: 4.575-59.203, P < .001). A pancreatic duct diameter of less than 3 mm and a soft pancreatic texture were found to be associated with POPF in the univariate analysis (P = .029, P = .032, respectively). Additionally, the prevalence of smoking and the median age were higher in patients with a CAS ≥50 (respectively, P = .011 and P = .052). Conclusions: CAS is an independent risk factor for clinically significant POPF. Preoperative CAS identification and management are vital to minimizing postoperative complications. Further studies are needed to confirm these findings.

腹腔动脉狭窄对胰十二指肠切除术后胰瘘发生率的影响。
腹腔动脉狭窄(Celiac artery stenosis, CAS)可通过损害上腹部脏器动脉灌注而加重术后并发症。本研究评估了胰十二指肠切除术患者中CAS的发生率及其与临床上显著的术后胰瘘(POPF)的关系。方法:回顾性分析2017 - 2022年间行胰十二指肠切除术的151例患者。通过术前计算机断层扫描评估CAS,狭窄阈值≥50%。多因素logistic回归确定了POPF的危险因素。结果:17.2%的患者发生CAS≥50%,17.9%的患者发生B/C级POPF。在CAS≥50%的患者中,发生POPF的风险显著增加(优势比:16.458,95%可信区间:4.575 ~ 59.203,P < 0.001)。单因素分析发现,胰管直径小于3mm和胰腺质地柔软与POPF相关(P = 0.029, P = 0.032)。此外,在CAS≥50的患者中,吸烟患病率和中位年龄更高(分别P = 0.011和P = 0.052)。结论:CAS是临床显著性POPF的独立危险因素。术前CAS的识别和处理对于减少术后并发症至关重要。需要进一步的研究来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.90
自引率
0.00%
发文量
163
审稿时长
3 months
期刊介绍: Journal of Laparoendoscopic & Advanced Surgical Techniques (JLAST) is the leading international peer-reviewed journal for practicing surgeons who want to keep up with the latest thinking and advanced surgical technologies in laparoscopy, endoscopy, NOTES, and robotics. The Journal is ideally suited to surgeons who are early adopters of new technology and techniques. Recognizing that many new technologies and techniques have significant overlap with several surgical specialties, JLAST is the first journal to focus on these topics both in general and pediatric surgery, and includes other surgical subspecialties such as: urology, gynecologic surgery, thoracic surgery, and more.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信