Optical coherence tomography as a potential biomarker for the logopenic variant of primary progressive aphasia: A cross-sectional prospective study.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2025-09-23 eCollection Date: 2025-07-01 DOI:10.1002/dad2.70188

Fei Wu, Monica Lavoie, Mélanie Hébert, Ali Dirani, Robert Laforce

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Abstract

Background: Optical coherence tomography (OCT) and OCT angiography (OCT-A) have been studied as biomarkers for Alzheimer's disease (AD), with promising results. Nevertheless, their potential in the logopenic variant of primary progressive aphasia (lvPPA), which shares the same amyloid pathology, has not yet been explored. This work aimed to characterize retinal changes in lvPPA compared to healthy controls.

Methods: Ten participants with lvPPA and eleven controls underwent OCT and OCT-A imaging. Amyloid pathology in lvPPA was confirmed by lumbar puncture. Retinal parameters included retinal nerve fiber layer (RNFL) thickness and foveal avascular zone (FAZ).

Results: Compared to controls, lvPPA participants exhibited reduced RNFL thickness in the temporal sector (p = 0.013) and significantly decreased FAZ circularity (p = 0.002).

Discussion: RNFL thinning may reflect trans-synaptic degeneration from cortical atrophy, while reduced FAZ circularity suggests early microvascular changes related to amyloid burden. Our findings support OCT and OCT-A as potential biomarkers for lvPPA.

Highlights: For the first time, OCT and OCT-A are studied as potential biomarkers for lvPPA.Compared to healthy controls, retinal nerve thickness is decreased in lvPPA patients.Retinal vasculature exhibits structural alterations in lvPPA patients.

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光学相干断层扫描作为原发性进行性失语症的潜在生物标志物：一项横断面前瞻性研究。

背景：光学相干断层扫描（OCT）和OCT血管造影（OCT- a）已被研究作为阿尔茨海默病（AD）的生物标志物，并取得了可喜的结果。然而，它们在原发性进行性失语症（lvPPA）中的潜力尚未被探索，后者具有相同的淀粉样蛋白病理。这项工作旨在描述lvPPA与健康对照组相比的视网膜变化。方法：10例lvPPA患者和11例对照组分别行OCT和OCT- a成像。经腰椎穿刺证实lvPPA的淀粉样蛋白病理。视网膜参数包括视网膜神经纤维层（RNFL）厚度和中央凹无血管区（FAZ）。结果：与对照组相比，lvPPA参与者颞区RNFL厚度降低（p = 0.013）， FAZ圆度显著降低（p = 0.002）。讨论：RNFL变薄可能反映皮层萎缩引起的突触变性，而FAZ圆度降低提示与淀粉样蛋白负荷相关的早期微血管改变。我们的研究结果支持OCT和OCT- a作为lvPPA潜在的生物标志物。重点：OCT和OCT- a作为lvPPA的潜在生物标志物首次被研究。与健康对照相比，lvPPA患者视网膜神经厚度减少。lvPPA患者视网膜血管结构发生改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.