Nasal Mucosa-Derived Ectodermal Mesenchymal Stem Cells for Parkinson's Therapy: From Developmental Insights to Application.

IF 4.6 2区医学 Q2 CELL & TISSUE ENGINEERING

Tissue Engineering. Part B, Reviews Pub Date : 2025-09-25 DOI:10.1177/19373341251376281

Zhe Wang, Qingtong Yu, Wenwen Deng, Jollibekov Berdiyar, Jiangnan Yu, Ximing Xu

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引用次数: 0

Abstract

Recent advancements in Parkinson's disease (PD) research have both enriched our pathophysiological understanding and challenged conventional therapeutic dogmas. The emerging application of ectodermal mesenchymal stem cells (EMSCs) derived from the cranial neural crest for neuronal regeneration represents a paradigm-shifting therapeutic modality, diverging fundamentally from traditional dopamine-replacement strategies. However, the fundamental mechanisms responsible for their remarkable neurorestorative potential in PD pathophysiology are still not fully understood. This comprehensive review synthesizes current evidence on the pleiotropic therapeutic capacities of EMSCs, focusing on their ectoderm-derived molecular signatures. Central to this review are developmental insights into nasal mucosa-derived EMSCs, particularly their Nestin⁺ identity, elevated connexin43, niche-specific paracrine activity, and robust dopaminergic differentiation capacity, to guide therapeutic translation for PD. Through systematic interrogation of nasal mucosa-derived EMSC physiology, we aim to establish an evidence-based platform for developing targeted neuroregenerative therapies.

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鼻黏膜来源的外胚层间充质干细胞用于帕金森病治疗：从发育观察到应用。

帕金森氏病（PD）研究的最新进展既丰富了我们对病理生理学的理解，也挑战了传统的治疗教条。颅神经嵴外胚层间充质干细胞（EMSCs）用于神经元再生的新兴应用代表了一种范式转换的治疗方式，从根本上不同于传统的多巴胺替代策略。然而，它们在PD病理生理学中具有显著的神经恢复潜力的基本机制仍未完全了解。本综述综合了目前关于EMSCs多效性治疗能力的证据，重点关注其外胚层来源的分子特征。本综述的核心是对鼻黏膜来源的EMSCs的发育见解，特别是它们的Nestin+身份，升高的连接蛋白43，小环境特异性旁分泌活性和强大的多巴胺能分化能力，以指导PD的治疗翻译。通过对鼻粘膜源性EMSC生理学的系统研究，我们旨在为开发靶向神经再生疗法建立一个基于证据的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

12.80

自引率

1.60%

发文量

150

期刊介绍： Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.