Outcome of Premature Infants Treated With Chemotherapy for Neuroblastoma in France.

IF 2.3 3区 医学 Q2 HEMATOLOGY
Dana Al Khalifa, Pascal Chastagner, Gudrun Schleiermacher, Julien Lejeune
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引用次数: 0

Abstract

Neuroblastoma is the most common extracranial solid tumor in children, and congenital forms account for 5% of all neuroblastoma cases. In utero diagnosis is very rare, and the progression leading to premature delivery for urgent treatment is exceptional. In some of these cases, chemotherapy is required after birth, given tumor progression that threatens the functional prognosis (dumbbell neuroblastoma), or even survival (Stage MS). However, the optimal doses of chemotherapy in premature newborns are not known. We present a retrospective cohort of six patients treated in French pediatric oncology centers in order to analyze treatment modalities, and report on their tolerance (five Grade 4 hematological toxicity, three septicemias) as well as the outcome of these newborns (two deaths, four remissions).

法国早产儿接受神经母细胞瘤化疗的结果
神经母细胞瘤是儿童最常见的颅外实体瘤,先天性形式占所有神经母细胞瘤病例的5%。在子宫内诊断是非常罕见的,进展导致早产的紧急治疗是例外。在这些病例中,由于肿瘤进展威胁到功能性预后(哑铃神经母细胞瘤),甚至生存(多发性硬化症期),在出生后需要化疗。然而,早产儿化疗的最佳剂量尚不清楚。我们对在法国儿科肿瘤中心接受治疗的6例患者进行了回顾性队列研究,以分析治疗方式,并报告其耐受性(5例4级血液毒性,3例败血症)以及这些新生儿的结局(2例死亡,4例缓解)。
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来源期刊
Pediatric Blood & Cancer
Pediatric Blood & Cancer 医学-小儿科
CiteScore
4.90
自引率
9.40%
发文量
546
审稿时长
1.5 months
期刊介绍: Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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