Ana Caroline da Silva Ferreira, Thayssa Gomes Farias, Ana Julia Cardoso Borges, Marcelle Abreu da Silva, Bruno Ricardo Barreto Pires, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
{"title":"Photobiomodulation by infrared radiation on hallmarks of cancer.","authors":"Ana Caroline da Silva Ferreira, Thayssa Gomes Farias, Ana Julia Cardoso Borges, Marcelle Abreu da Silva, Bruno Ricardo Barreto Pires, Andre Luiz Mencalha, Adenilson de Souza da Fonseca","doi":"10.1007/s10103-025-04625-2","DOIUrl":null,"url":null,"abstract":"<p><p>Photobiomodulation (PBM) is a therapeutic technique that utilizes non-ionizing radiation, such as infrared radiation, which is capable of stimulating or inhibiting biological processes. Cancer is characterized by uncontrolled cell growth and proliferation in any body structure, allowing it to invade other tissues. Cancer exhibits distinct biological characteristics, the so-called hallmarks of cancer. Despite the therapeutic benefits of PBM, and cancers affect millions of people worldwide, the mechanisms involved in PBM, as those induced by infrared A radiation, on cancer are not yet fully elucidated. Thus, we aimed to review the effects of PBM induced by infrared radiation on the hallmarks of cancer. For this, studies on the effects of PBM induced by infrared A radiation on in vitro and in vivo experimental models of cancer were accessed via MEDLINE/PubMed. The data accessed showed that effects of PBM induced by infrared A radiation were evaluated on four hallmarks of cancer (sustaining proliferative signaling, evading growth suppressors, genomic instability and mutation, and resisting cell death) but not on the other ten ones (enabling replicative immortality, non-mutational epigenetic reprogramming, avoiding immune destruction, tumor-promoting inflammation, polymorphic microbiomes, activating invasion and metastasis, inducing or accessing vasculature, senescent cells, deregulation cellular energetics, unlocking phenotypic plasticity). Thus, considering the therapeutic benefits of PBM, evaluation of the effects of PBM on the hallmarks of cancer can also bring such benefits to oncologic patients.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"385"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lasers in Medical Science","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10103-025-04625-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Photobiomodulation (PBM) is a therapeutic technique that utilizes non-ionizing radiation, such as infrared radiation, which is capable of stimulating or inhibiting biological processes. Cancer is characterized by uncontrolled cell growth and proliferation in any body structure, allowing it to invade other tissues. Cancer exhibits distinct biological characteristics, the so-called hallmarks of cancer. Despite the therapeutic benefits of PBM, and cancers affect millions of people worldwide, the mechanisms involved in PBM, as those induced by infrared A radiation, on cancer are not yet fully elucidated. Thus, we aimed to review the effects of PBM induced by infrared radiation on the hallmarks of cancer. For this, studies on the effects of PBM induced by infrared A radiation on in vitro and in vivo experimental models of cancer were accessed via MEDLINE/PubMed. The data accessed showed that effects of PBM induced by infrared A radiation were evaluated on four hallmarks of cancer (sustaining proliferative signaling, evading growth suppressors, genomic instability and mutation, and resisting cell death) but not on the other ten ones (enabling replicative immortality, non-mutational epigenetic reprogramming, avoiding immune destruction, tumor-promoting inflammation, polymorphic microbiomes, activating invasion and metastasis, inducing or accessing vasculature, senescent cells, deregulation cellular energetics, unlocking phenotypic plasticity). Thus, considering the therapeutic benefits of PBM, evaluation of the effects of PBM on the hallmarks of cancer can also bring such benefits to oncologic patients.
期刊介绍：
Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics.
The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.
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