{"title":"Diagnostic and Prognostic Predictive Value of Serum Selenium and Redox Biomarkers in Retinal Vein Occlusion.","authors":"Danqing Shen, Meixiu Li, Wencai Sun, Zhifu Tao","doi":"10.2147/IJGM.S522918","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic efficacy and prognostic predictive value of serum selenium (Sse) and redox biomarkers in retinal vein occlusion (RVO).</p><p><strong>Methods: </strong>A prospective analysis was conducted on 112 RVO patients (RVO Group) admitted to the hospital between January 2022 and February 2024, along with 112 non-RVO ophthalmic patients (non-RVO Group) during the same period. The levels of Sse and redox factors [high mobility group protein B1 (HMGB1), reduced glutathione (GSH), nitric oxide (NO), and superoxide dismutase (SOD)] were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic efficacy for RVO. The RVO Group received treatment and was divided into poor prognosis group and good prognosis group based on prognosis. The changes in Sse and redox biomarker levels were compared to analyze factors influencing RVO patient prognosis, and a nomogram was constructed to validate the calibration curve.</p><p><strong>Results: </strong>Compared with the non-RVO group, the levels of Sse, GSH, and SOD were lower, while the levels of HMGB1 and NO were higher in the RVO group (<i>P</i> <0.05). The ROC curve showed that Sse and various oxidative stress factors had good diagnostic efficacy for RVO. In the Poor Prognosis Group, Sse, GSH, NO, and SOD levels were lower than those in the Good Prognosis Group, while HMGB1 levels were higher than those in the Good Prognosis Group (<i>P</i> <0.05). Cox regression analysis showed that all these indicators were factors influencing the prognosis of RVO patients (all P < 0.05). Additionally, the consistency of theroc curves constructed using these factors was good, and the calibration curves were close to the ideal curve.</p><p><strong>Conclusion: </strong>The combined detection of Sse and redox biomarkers can effectively assist in RVO diagnosis, while their dynamic changes have important clinical value in prognosis evaluation.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5731-5742"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456751/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of General Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJGM.S522918","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the diagnostic efficacy and prognostic predictive value of serum selenium (Sse) and redox biomarkers in retinal vein occlusion (RVO).
Methods: A prospective analysis was conducted on 112 RVO patients (RVO Group) admitted to the hospital between January 2022 and February 2024, along with 112 non-RVO ophthalmic patients (non-RVO Group) during the same period. The levels of Sse and redox factors [high mobility group protein B1 (HMGB1), reduced glutathione (GSH), nitric oxide (NO), and superoxide dismutase (SOD)] were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic efficacy for RVO. The RVO Group received treatment and was divided into poor prognosis group and good prognosis group based on prognosis. The changes in Sse and redox biomarker levels were compared to analyze factors influencing RVO patient prognosis, and a nomogram was constructed to validate the calibration curve.
Results: Compared with the non-RVO group, the levels of Sse, GSH, and SOD were lower, while the levels of HMGB1 and NO were higher in the RVO group (P <0.05). The ROC curve showed that Sse and various oxidative stress factors had good diagnostic efficacy for RVO. In the Poor Prognosis Group, Sse, GSH, NO, and SOD levels were lower than those in the Good Prognosis Group, while HMGB1 levels were higher than those in the Good Prognosis Group (P <0.05). Cox regression analysis showed that all these indicators were factors influencing the prognosis of RVO patients (all P < 0.05). Additionally, the consistency of theroc curves constructed using these factors was good, and the calibration curves were close to the ideal curve.
Conclusion: The combined detection of Sse and redox biomarkers can effectively assist in RVO diagnosis, while their dynamic changes have important clinical value in prognosis evaluation.
期刊介绍：
The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas.
A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal.
As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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