{"title":"Applications of New Generation Sequencing (NGS) in Ocular Oncology.","authors":"Mizuki Tagami, Shigeru Honda","doi":"10.1097/IIO.0000000000000584","DOIUrl":null,"url":null,"abstract":"<p><p>Next-generation sequencing (NGS) has revolutionized cancer genomics, offering unparalleled insights into the molecular landscape of various malignancies, including ocular cancers. This review explores the role of NGS in ocular oncology, highlighting its impact on understanding genetic alterations, identifying biomarkers, and advancing personalized treatment approaches. Key applications in uveal melanoma, retinoblastoma, and other ocular tumors, including ocular adnexa lymphoma and IgG4-related ophthalmic disease are discussed, along with the challenges and future directions in the field. As sequencing technologies continue to evolve, integrating NGS into clinical practice promises to enhance early diagnosis, risk assessment, and therapeutic strategies in ocular oncology.</p>","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 4","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459143/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Ophthalmology Clinics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IIO.0000000000000584","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Next-generation sequencing (NGS) has revolutionized cancer genomics, offering unparalleled insights into the molecular landscape of various malignancies, including ocular cancers. This review explores the role of NGS in ocular oncology, highlighting its impact on understanding genetic alterations, identifying biomarkers, and advancing personalized treatment approaches. Key applications in uveal melanoma, retinoblastoma, and other ocular tumors, including ocular adnexa lymphoma and IgG4-related ophthalmic disease are discussed, along with the challenges and future directions in the field. As sequencing technologies continue to evolve, integrating NGS into clinical practice promises to enhance early diagnosis, risk assessment, and therapeutic strategies in ocular oncology.
期刊介绍：
International Ophthalmology Clinics is a valuable resource for any medical professional seeking to stay informed and up-to-date regarding developments in this dynamic specialty. Each issue of this quarterly publication presents a comprehensive review of a single topic in a new or changing area of ophthalmology. The timely, tightly focused review articles found in this publication give ophthalmologists the opportunity to benefit from the knowledge of leading experts in this rapidly changing field.
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