Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1647365

Fangfang Huang, Huizhen Li, Haizhen You, Yuantao Su, Huijuan Peng, Wenchong Du, Jing Hua

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引用次数: 0

Abstract

Objective: Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.

Methods: Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.

Results: A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg18187326 (FAM45A) and cg11968956 (FAM184A) were significantly associated with both total motor and gross motor scores. In addition, cg03597174 (SEZ6) was negatively associated, while cg05986449 (GPD2) was positively associated with gross motor function.

Conclusion: These findings provide preliminary evidence that specific DNA methylation alterations may influence early motor development and potentially contribute to the pathogenesis of DCD. DNA methylation markers may serve as novel biomarkers for early diagnosis and targeted intervention in children with DCD.

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发育协调障碍的表观遗传修饰：DNA甲基化与运动表现之间的关系。

目的：发育性协调障碍（Developmental Coordination Disorder， DCD）是一种常见的以运动协调功能受损为特征的神经发育疾病。然而，DCD的生物学机制仍不清楚。本研究旨在探讨DNA甲基化在DCD发病机制中的潜在作用。方法：采用DCD患儿和非DCD患儿外周血标本进行全基因组DNA甲基化分析。选择42个关键差异甲基化探针（dmp），使用MethylTarget™测序进行靶向验证。结果：共检出416个dmp。使用Bumphunter和ProbeLasso算法，分别鉴定了48和22个差异甲基化区域（DMRs）。在关键的dmp中，cg18187326 （FAM45A）和cg11968956 （FAM184A）的甲基化水平与总运动和大运动得分显著相关。此外，cg03597174 （SEZ6）与大运动功能呈负相关，而cg05986449 （GPD2）与大运动功能呈正相关。结论：这些发现为特异性DNA甲基化改变可能影响早期运动发育并可能参与DCD的发病机制提供了初步证据。DNA甲基化标记物可能作为DCD儿童早期诊断和靶向干预的新型生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.