Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report.

Abstract

Dermatomyositis (DM) is a rare autoimmune disease characterized by inflammatory involvement of skin and muscles, often associated with malignancy, particularly in the presence of anti-transcription intermediary factor 1 gamma (TIF-1γ) antibodies. This case report describes a 57-year-old Senegalese man with anti-TIF-1γ-positive DM and colorectal adenocarcinoma with liver metastases, presenting with severe dermatological symptoms such as ulcerations, the "red on white" sign, and scalp pustulosis, as well as systemic features including dysphagia and muscle weakness. Diagnosis was confirmed through clinical evaluation, serological testing, and histopathology. Treatment with corticosteroids, intravenous immunoglobulin (IVIG), and surgical tumor resection led to significant improvement. This case underscores the importance of recognizing DM's dermatological signs, conducting thorough malignancy screening, and implementing a multidisciplinary approach for effective management and improved outcomes, given the rarity of the association with colorectal cancer.