{"title":"Structural Change of Neurotransmitter Amine with CO<sub>2</sub> in Water: Formation of Covalently Bound Carbamic Acid.","authors":"Keitaro Shiota, Ryo Murakami, Fuyuhiko Inagaki","doi":"10.1248/cpb.c25-00463","DOIUrl":null,"url":null,"abstract":"<p><p>Structural transformation changes the activity of biological reactions. Neurotransmitter aralkylamines, such as phenethylamine, tyramine, dopamine, tryptamine, serotonin, and histamine, absorb aerial CO<sub>2</sub>, and heteronuclear multiple bond connectivity (HMBC) correlations between the carbon derived from CO<sub>2</sub> and the α-hydrogen of the several amines were confirmed in the D<sub>2</sub>O solution. The isolation of methyl carbamate from phenethylamine and CO<sub>2</sub> in water with TMSCHN<sub>2</sub> also supported the formation of covalently bound carbamic acid in the amine aqueous solution containing CO<sub>2</sub>. Therefore, it is suggested that CO<sub>2</sub> produced in the body would react with neurotransmitter amines to form covalently bound carbamic acid, which might affect biological reactions.</p>","PeriodicalId":9773,"journal":{"name":"Chemical & pharmaceutical bulletin","volume":"73 9","pages":"914-918"},"PeriodicalIF":1.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical & pharmaceutical bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1248/cpb.c25-00463","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Structural transformation changes the activity of biological reactions. Neurotransmitter aralkylamines, such as phenethylamine, tyramine, dopamine, tryptamine, serotonin, and histamine, absorb aerial CO2, and heteronuclear multiple bond connectivity (HMBC) correlations between the carbon derived from CO2 and the α-hydrogen of the several amines were confirmed in the D2O solution. The isolation of methyl carbamate from phenethylamine and CO2 in water with TMSCHN2 also supported the formation of covalently bound carbamic acid in the amine aqueous solution containing CO2. Therefore, it is suggested that CO2 produced in the body would react with neurotransmitter amines to form covalently bound carbamic acid, which might affect biological reactions.
期刊介绍：
The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below.
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